While the excess risk of neurological disorders in kidney impairment is well-known, mechanisms behind this link are widely understudied. Decline in kidney function, even in early stages, leads to the buildup of uremic toxins in body. Accumulation of uremic toxins is suggested as a culprit for triggering multiple biologic pathways that can affect brain structural and functional integrity. Metabolic profiling is a high-throughput analysis of metabolites and can be utilized to identify uremic toxins. In this proposal, we aim to identify individual or networks of uremic metabolites and examine their solo or joint associations with impaired cognitive function. The aims will be addressed in the framework of the CARDIA Study, including 165 participants with pre-clinical stages of kidney impairment (G3a, G2, and G1). Identification of uremic toxins with adverse neurological outcomes is of great importance as it can result in developing strategies to suppress their production and accelerate their removal.
|Effective start/end date||7/1/19 → 9/19/19|
- University of Pennsylvania (574485//5-U01-DK-103225-05)
- National Institute of Diabetes, Digestive and Kidney Diseases (574485//5-U01-DK-103225-05)