The role of A-to-I RNA editing in advanced prostate cancer

Project: Research project

Description

We anticipate that by protein-protein interaction, EZH2 may help ADAR bind to new RNA sites or prohibit ADAR to bind to its targets because EZH2 has a RNA binding domain and directly binds to RNA. Because both ADAR and EZH2 are elevated in advanced PCa, they may coordinate to regulate their shared targets and promote PCa initiation and progression.
StatusActive
Effective start/end date9/30/199/29/22

Funding

  • U.S. Army Medical Research and Materiel Command (W81XWH1910563)

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RNA Editing
Prostatic Neoplasms
RNA
Proteins
immune RNA
Haemophilus influenzae type b-polysaccharide vaccine-diphtheria toxoid conjugate
RNA-Binding Motifs