The Role of CD44+ Breast Cancer Stem Cells in Exosome and Immune Regulation

Project: Research project

Project Details

Description

We hypothesize that CD44+ CSCs maintain CD81 levels to promote exosome production, immune suppression, and CSC properties (stemness). We aim to examine the effects of modulated CD44 and CD81 on cancer exosome-mediated cross talks with immune cells, and to determine the intrinsic role of CD81 in CSC stemness and metastasis.
StatusActive
Effective start/end date9/1/188/31/20

Funding

  • Northwestern Memorial Hospital (AGMT 12/3/18)

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