Blockages in blood vessels caused by advanced atherosclerosis frequently lead to heart attacks, strokes, foot ulcers, gangrene, and limb loss and can be treated by balloon angioplasty/stenting and bypass surgery. However, the rate of treatment failure due to “restenosis,” or recurrent narrowing of arteries due to excessive thickening and scarring of the vessel wall, can reach 50% in 5 years. In this research program, we will investigate the mechanisms by which short chain fatty acids and other gut microbe-derived metabolites regulate the healing response of blood vessels and whether strategies for changing the composition and activity of gut microbes can reduce the risk of restenosis after cardiovascular interventions.
|Effective start/end date||1/25/16 → 12/31/20|
- National Heart, Lung, and Blood Institute (5K08HL130601-05)