The Role of Mutations in the TCR Signaling Complex in Cutaneous T Cell Lymphoma

Project: Research project

Project Details

Description

We hypothesize that these TCR-associated mutations underlie the oncogenic alterations in the TCR signaling cascade in CTCL. In particular, we will investigate whether these mutations enable CTCL’s capacity for limitless proliferation and its overproduction of immunosuppressive factors. Because these processes are most often responsible for patient mortality in CTCL, we predict that these studies will therefore be critical for the eventual development of a cure for this intractable disease. Specific Aims: 1. To elucidate the role of CTCL mutations on T cell receptor signaling. 2. To elucidate the role of CTCL mutations on TCR-dependent proliferation and production of immunosuppressive factors.
StatusFinished
Effective start/end date7/1/166/30/19

Funding

  • Damon Runyon Cancer Research Foundation (2016095)

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