The role of non-classical monocytes in the pathogenesis of sterile autoimmune disease

Project: Research project

Project Details


We hypothesize that under steady state conditions the resident synovial macrophage population functions to prevent inflammation; however, during inflammatory arthritis the non-classical monocytes extravasate into the joint and become inflammatory macrophages leading to destructive RA-like disease. Following a signal that induces resolution of disease (i.e. anti-TNF therapy), macrophages alter their phenotype and become polarized towards a regulatory/remission in situ without the requirement of monocytes from circulation.
Effective start/end date9/1/148/31/18


  • United States-Israel Binational Science Foundation (2013247)


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