The Unfolded Protein Response (UPR) in Liver Transplant Patients with Cholestasis, Lay Title: A novel protective mechanism for cholestasis in liver transplant patients. The central hypothesis of this study is that cholestasis causes ER stress and activation of the the protective hepatic UPR pathways. Inability or inappropriate UPR activation causes worsened cholestatic liver injury. The purpose of this pilot-feasibility study is to characterize the specific liver UPR signaling pathways that are associated with post-liver transplant cholestasis. The long-term goal of this line of investigation is to identify novel therapeutic targets for treatment of cholestasis and to discover potential prognostic markers for clinical outcomes in liver transplant patients.
|Effective start/end date
|7/1/20 → 9/30/21
- Northwestern Memorial Hospital (Letter - 05/27/2020 // Letter - 05/27/2020)
- Digestive Health Foundation (Letter - 05/27/2020 // Letter - 05/27/2020)
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