TRANSFORM-HF (ToRsemide compArisoN with furoSemide FOR Management of Heart Failure)

The purpose of this research study is to compare the two most common loop diuretics, also called water pills, furosemide (“lasix”) and torsemide (“demadex”). Comparing the two diuretics will help determine which is best for patients who have heart failure. Participants who enter into the study will have their first study visit while in the hospital. Before participants start their water pill, they will be randomly chosen to take either furosemide or torsemide. All other study visits after the visit in the hospital will be done by phone. These calls are scheduled at about 30 days, then every 6 months for up to about 30 months. During the phone calls, the participant will be asked how they are feeling, the quality of their life, what medications they are taking, and if they have been back in the hospital. Participation in the study will not change regularly scheduled visits to the doctor(s).