Traumatic brain injury afflicts approximately three million Americans every year with a high rate of long-term cognitive and psychiatric morbidity. Chronic neuroinflammation resulting from the constitutive activation of microglia is complicit in this process and represents a complex interplay between the injured brain, microglia, and the gut microbiome via the gut-brain axis. However, the mechanism(s) underlying gut microbiota-microglia interaction have yet to be elucidated.
|Effective start/end date||8/1/22 → 7/31/27|
- National Institute of Neurological Disorders and Stroke (5R01NS127865-02)
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