Trauma, the gut, and the brain: the gut microbiota-microglia axis in traumatic brain injury

Project: Research project

Project Details

Description

Traumatic brain injury afflicts approximately three million Americans every year with a high rate of long-term cognitive and psychiatric morbidity. Chronic neuroinflammation resulting from the constitutive activation of microglia is complicit in this process and represents a complex interplay between the injured brain, microglia, and the gut microbiome via the gut-brain axis. However, the mechanism(s) underlying gut microbiota-microglia interaction have yet to be elucidated.
StatusActive
Effective start/end date8/1/227/31/27

Funding

  • National Institute of Neurological Disorders and Stroke (1R01NS127865-01)

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