Ubiquitin pathway activation: A new strategy for treating ALS

Project: Research project

Description

We will test small molecules for their ability to activate protein recycling pathways using some of our existing compounds as well as screening focused compound libraries for new drug candidates. We hope to find several new drug candidates which will undergo additional testing in animal models in future studies. Ultimately, we envision that activating protein recycling will be beneficial to the majority of ALS cases where protein aggregates are found and possibly in other neurodegenerative diseases.
StatusFinished
Effective start/end date4/15/179/30/19

Funding

  • U.S. Army Medical Research and Materiel Command (W81XWH-17-1-0086)

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Ubiquitin
Recycling
Neurodegenerative Diseases
Pharmaceutical Preparations
Libraries
Proteins
Animal Models
Protein Aggregates