UIUC Neuroproteomics and Neurometabolomics Center on Cell to Cell Signaling

The research team develops next-generation proteomics using whole proteins (i.e., the “Top Down” approach) and efficiently translates this frontier approach to multiple research projects. The team uses a diversity of commercial and custom sample handling approaches, mass spectrometers, and software to apply high performance and cutting-edge proteomics to a variety of cell lines, tissues, and mammalian tissues/fluids. The research group has two fully-equipped wet labs and sufficient office space for over 20 staff members and students. The Kelleher Research Group has access to over a dozen mass spectrometers. These instruments are capable of high mass accuracy measurements of proteins, peptides and metabolites. Four are 7 or 12 Tesla LTQ-FTs (Thermo Fisher). The group also has access to several other mass spectrometers: a TSQ Quantum Ultra Triple Quadrupole, an Orbitrap Elite, two Q-Exactives, an Exactive, and a Waters Q-TOF Premier, among others. Finally, the Kelleher Research Group supports a large network, including a 40TB storage server and a 168 core computing cluster for top down proteomics data analysis and processing.