Uncovering New Therapeutics and Neuroprotective Mechanisms for TBI

Project: Research project

Project Details


Traumatic brain injury (TBI) is one of the leading causes of death and disability in the developed world (Helmick et al. 2015; Mathias and Alvaro 2012; Collen et al. 2012). Since 2000 more than 300,000 Service members were diagnosed with traumatic brain injury (TBI). Sleep disorders occur in 97% of military personnel that develop TBI during deployment and often persist for months or years. The clinical impact of TBI is highlighted not only by its high mortality rate – TBI contributes to a third of all injury-related deaths in the United States - but the significant long-term health complications reported by those who survive their injuries, including persistent sleep disorders, affect not only the patients but also those around them. Yet treatments for TBI are limited due to a lack of understanding of the mechanisms leading to neuropathology in vivo. We propose to use in vivo screening approaches to identify novel compounds and genetic pathways to ameliorate TBI induced mortality and sleep disorders in a newly developed animal model of TBI.
Effective start/end date4/1/203/31/23


  • U.S. Army Medical Research and Materiel Command (W81XWH2010211)


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