Uncovering the mechanism of DYRK1A in lymphopoiesis and acute lymphoblastic leukemia

  • Crispino, John D (PD/PI)

Project: Research project

Project Details

Description

My lab has shown that the chromosome 21 kinase DYRK1A is necessary for normal
lymphocyte development in part through the Cyclin D3-Rb-E2F pathway(1). This mechanism
appears to govern the switch between proliferation and quiescence, but the way in which DYRK1A
regulates differentiation is unclear. In addition to disruption of normal development, the loss of Dyrk1a
also impairs proliferative ability of acute lymphoblastic leukemia (ALL) cells, suggesting that it has a
multi-faceted role in lymphocyte biology. My goal is to illustrate a complete mechanism of DYRK1A in
developing lymphocytes and to see how this changes upon leukemic transformation. I hypothesize
that DYRK1A regulates a number of intracellular pathways that regulate the growth and differentiation
of lymphoid cells, and that its dysregulation contributes to ALL.
StatusFinished
Effective start/end date7/1/166/30/17

Funding

  • American Society of Hematology (AGREEMENT 4/18/16)

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.