Unraveling the Mechanisms of HIV Persistence and Rebound

Current studies in the non-human primate model led to surprising, important findings such as the possible dependence of the reservoir on myeloid cell infection and to the development of groundbreaking technologies for the investigation of the tissue reservoir. By leveraging these new insights and technologies, we will investigate the dynamics of the HIV reservoir with unprecedented, unbiased resolution, including dissecting the role of little known, tissue resident cell targets of HIV infection of myeloid origins.