Validating Photobiomodulation Light Dosing Regimen for Preventing and Reducing Noise-Induced Hearing Loss

Project: Research project

Project Details

Description

Investigators at Northwestern University (Drs. Tan and Richter) will establish the animal protocol, order the mice, measure baseline hearing function (ABRs), implant the light-delivering devices into the ear canals of the mice, control the light exposure following the protocol by RayBalance. After establishing the ABR baseline, the light treatment will start as outlined in the protocol by RayBalance. After two days of treatment, the Richter lab will expose the mice to noise (8-16 kHz, 110 dB SPL, 2 hours). After the noise exposure, treatment will continue for another five days, and ABRs thresholds will be determined at post-exposure days 3 and 7. Following the last hearing assessment, mice will be euthanized, and the cochleae are sampled for histology. Study progress will be shared with RayBalance, and the results will be given to RayBalance for analysis and interpretation.
StatusActive
Effective start/end date8/1/217/31/22

Funding

  • RayBalance, Inc. (Tan AGMT 8/19/21)

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