Vulnerable Substrate for AF and Stroke

Project: Research project

Description

We have designed a proposal that will develop a comprehensive understanding of the role of the underlying atrial substrate in the pathogenesis of AF and its major morbidity - thromboembolic stroke. In order to best achieve our stated goal, Northwestern’s Center for Atrial Fibrillation (AF) will leverage our breadth and depth of expertise in clinical cardiac electrophysiology, advanced cardiac imaging, cellular and translational electrophysiology, epidemiology, neurology, and biostatistics to characterize fundamental aspects of the structural, functional, and electrophysiolgic aspects of the left atrial (LA) myopathy that promote AF and AF-related neurological events. The scientific premise of this project is based on the emerging concept of the LA myopathy1as the underlying substrate for AF and AF-related stroke and our unique abilities at Northwestern to assess critical aspects of the disease process using a combination of cutting-edge cardiovascular magnetic resonance (CMR) imaging, electrophysiologic markers of oxidative stress, signal processing, population studies, and catheter ablation expertise.
StatusActive
Effective start/end date7/1/186/30/22

Funding

  • American Heart Association (18SFRN34110170)

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Atrial Fibrillation
Stroke
Cardiac Electrophysiology
Biostatistics
Catheter Ablation
Electrophysiology
Muscular Diseases
Neurology
Epidemiology
Oxidative Stress
Magnetic Resonance Imaging
Morbidity
Population