We have designed a proposal that will develop a comprehensive understanding of the role of the underlying atrial substrate in the pathogenesis of AF and its major morbidity - thromboembolic stroke. In order to best achieve our stated goal, Northwestern’s Center for Atrial Fibrillation (AF) will leverage our breadth and depth of expertise in clinical cardiac electrophysiology, advanced cardiac imaging, cellular and translational electrophysiology, epidemiology, neurology, and biostatistics to characterize fundamental aspects of the structural, functional, and electrophysiolgic aspects of the left atrial (LA) myopathy that promote AF and AF-related neurological events. The scientific premise of this project is based on the emerging concept of the LA myopathy1as the underlying substrate for AF and AF-related stroke and our unique abilities at Northwestern to assess critical aspects of the disease process using a combination of cutting-edge cardiovascular magnetic resonance (CMR) imaging, electrophysiologic markers of oxidative stress, signal processing, population studies, and catheter ablation expertise.
|Effective start/end date||7/1/18 → 6/30/22|
- American Heart Association (18SFRN34110170)