α-Amino acid analogues as mechanism-based inactivators of γ-aminobutyric acid aminotransferase

Mark Hans Hopkins*, Richard B. Silverman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

γ- and β-Amino acids have been used previously to inactivate γ-aminobutyric acid aminotransferase. Here it is shown that β-halo-, β-phospho-, β-sulpho-L-alanine, and vinyl-L-glycine, all α-amino acids, are time dependent inactivators of purified γ-aminobutyrate aminotransferase. Observations that this inactivation is stereospecific and requires the formation of a Michaelis complex support a catalytic mechanism for this process. α-Amino acids are time dependent inactivators of purified γ-aminobutyrate aminotransferase.

Original languageEnglish (US)
Pages (from-to)1357-1360
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume2
Issue number11
DOIs
StatePublished - Nov 1992

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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