α-amino acid analogues as mechanism-based inactivators of γ-aminobutyric acid aminotransferase

M. H. Hopkins, R. B. Silverman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

γ- and β-Amino acids have been used previously to inactivate γ-aminobutyric acid aminotransferase. Here it is shown that β-halo, β-phospho-, β-sulpho-L-alanine, and vinyl-L-glycine, all α-amino acids, are time dependent inactivators of purified γ-aminobutyrate aminotransferase. Observations that this inactivation is stereospecific and requires the formation of a Michaelis complex support a catalytic mechanism for this process.

Original languageEnglish (US)
Pages (from-to)1371-1374
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume2
Issue number11
DOIs
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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