α-Synuclein at the Synaptic Gate

D. James Surmeier

doi:10.1016/j.neuron.2009.12.030

α-Synuclein at the Synaptic Gate

D. James Surmeier^*

^*Corresponding author for this work

Neuroscience

Research output: Contribution to journal › Short survey › peer-review

7 Scopus citations

Abstract

Only doubling or tripling α-synuclein expression significantly increases the risk of developing Parkinson's disease. In this issue of Neuron, Nemani et al. show that this modest overexpression of α-synuclein does not lead to obvious toxicity in the near term, but impairs glutamate and dopamine release, potentially leading to broad network dysfunction and eventual pathology.

Original language	English (US)
Pages (from-to)	3-4
Number of pages	2
Journal	Neuron
Volume	65
Issue number	1
DOIs	https://doi.org/10.1016/j.neuron.2009.12.030
State	Published - Jan 14 2010

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neuron.2009.12.030

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abstract = "Only doubling or tripling α-synuclein expression significantly increases the risk of developing Parkinson's disease. In this issue of Neuron, Nemani et al. show that this modest overexpression of α-synuclein does not lead to obvious toxicity in the near term, but impairs glutamate and dopamine release, potentially leading to broad network dysfunction and eventual pathology.",

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α-Synuclein at the Synaptic Gate

Abstract

ASJC Scopus subject areas

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