α-Synuclein at the Synaptic Gate

Dalton James Surmeier Jr*

*Corresponding author for this work

Research output: Contribution to journalShort survey

4 Scopus citations

Abstract

Only doubling or tripling α-synuclein expression significantly increases the risk of developing Parkinson's disease. In this issue of Neuron, Nemani et al. show that this modest overexpression of α-synuclein does not lead to obvious toxicity in the near term, but impairs glutamate and dopamine release, potentially leading to broad network dysfunction and eventual pathology.

Original languageEnglish (US)
Pages (from-to)3-4
Number of pages2
JournalNeuron
Volume65
Issue number1
DOIs
Publication statusPublished - Jan 14 2010

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ASJC Scopus subject areas

  • Neuroscience(all)

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