α-Synuclein at the Synaptic Gate

D. James Surmeier*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

6 Scopus citations

Abstract

Only doubling or tripling α-synuclein expression significantly increases the risk of developing Parkinson's disease. In this issue of Neuron, Nemani et al. show that this modest overexpression of α-synuclein does not lead to obvious toxicity in the near term, but impairs glutamate and dopamine release, potentially leading to broad network dysfunction and eventual pathology.

Original languageEnglish (US)
Pages (from-to)3-4
Number of pages2
JournalNeuron
Volume65
Issue number1
DOIs
StatePublished - Jan 14 2010

ASJC Scopus subject areas

  • Neuroscience(all)

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