α1-Antitrypsin deficiency-associated panniculitis: Resolution with intravenous α1-antitrypsin administration and liver transplantation

K. O'Riordan, A. Blei, M. S. Rao, M. Abecassis*

*Corresponding author for this work

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Panniculitis is a rare complication of α1-antitrypsin (A1AT) deficiency that is characterized by acute inflammatory infiltrate and fat necrosis. Different treatment strategies are used to provide symptomatic relief. Here we describe two patients with homozygous A1AT deficiency who developed panniculitis and were successfully treated with A1AT replacement. The patient who received a liver transplant experienced complete resolution of the skin lesions. The patient who received A1AT intravenously showed complete response, but the skin lesions recurred when the levels of A1AT fell below 50 mg/100 ml. Panniculitis secondary to A1AT deficiency can be successfully treated with liver transplantation or intravenous infusion of A1AT.

Original languageEnglish (US)
Pages (from-to)480-482
Number of pages3
JournalTransplantation
Volume63
Issue number3
DOIs
StatePublished - Feb 15 1997

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ASJC Scopus subject areas

  • Transplantation

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