α2,3-Sialyltransferase mRNA and α2,3-linked glycoprotein sialylation are increased in malignant gliomas

Hirotaka Yamamoto; Tasuku Saito; Yoichi Kaneko; Donna Kersey; Voon Wee Yong; Eric G. Bremer; Edward Mkrdichian; Leonard Cerullo; Jan Leestma; Joseph R. Moskal

doi:10.1016/S0006-8993(97)00241-2

α2,3-Sialyltransferase mRNA and α2,3-linked glycoprotein sialylation are increased in malignant gliomas

Hirotaka Yamamoto, Tasuku Saito, Yoichi Kaneko, Donna Kersey, Voon Wee Yong, Eric G. Bremer, Edward Mkrdichian, Leonard Cerullo, Jan Leestma, Joseph R. Moskal^*

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

CMP-NeuAc: Galβ1,3(4)GlcNAc α2,3-sialyltransferase (α2,3-ST) mRNA was expressed in human glioma specimens, human fetal astrocytes, and a panel of brain tumor cell lines. Maackia amurensis agglutinin staining revealed the presence of α2,3-linked sialic acids on glioma cell surfaces and extracellular matrices whereas normal human adult astrocytes were negative. Increased expression of α2,3-linked glycoprotein sialylation may play a role in glial tumorigenesis.

Original language	English (US)
Pages (from-to)	175-179
Number of pages	5
Journal	Brain research
Volume	755
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(97)00241-2
State	Published - Apr 25 1997

Keywords

brain tumor
glioma
glycoprotein
sialic acid
sialyltransferase

ASJC Scopus subject areas

Clinical Neurology
Molecular Biology
General Neuroscience
Developmental Biology

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10.1016/S0006-8993(97)00241-2

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@article{acf8984c62b944cb82d23459cff999cc,

title = "α2,3-Sialyltransferase mRNA and α2,3-linked glycoprotein sialylation are increased in malignant gliomas",

abstract = "CMP-NeuAc: Galβ1,3(4)GlcNAc α2,3-sialyltransferase (α2,3-ST) mRNA was expressed in human glioma specimens, human fetal astrocytes, and a panel of brain tumor cell lines. Maackia amurensis agglutinin staining revealed the presence of α2,3-linked sialic acids on glioma cell surfaces and extracellular matrices whereas normal human adult astrocytes were negative. Increased expression of α2,3-linked glycoprotein sialylation may play a role in glial tumorigenesis.",

keywords = "brain tumor, glioma, glycoprotein, sialic acid, sialyltransferase",

author = "Hirotaka Yamamoto and Tasuku Saito and Yoichi Kaneko and Donna Kersey and Yong, {Voon Wee} and Bremer, {Eric G.} and Edward Mkrdichian and Leonard Cerullo and Jan Leestma and Moskal, {Joseph R.}",

note = "Funding Information: The authors would like to gratefully acknowledge Mr. Kevin Cramer for his assistance in obtaining fresh tumor specimens. Work was supported in part by grants from the Illinois division of The American Cancer Society (H.Y.), The Buchanan Foundation (J.M.), The Brach Foundation (J.M.), and The Falk Foundation (J.M.). Copyright: Copyright 2015 Elsevier B.V., All rights reserved.",

year = "1997",

month = apr,

day = "25",

doi = "10.1016/S0006-8993(97)00241-2",

language = "English (US)",

volume = "755",

pages = "175--179",

journal = "Brain research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - α2,3-Sialyltransferase mRNA and α2,3-linked glycoprotein sialylation are increased in malignant gliomas

AU - Yamamoto, Hirotaka

AU - Saito, Tasuku

AU - Kaneko, Yoichi

AU - Kersey, Donna

AU - Yong, Voon Wee

AU - Bremer, Eric G.

AU - Mkrdichian, Edward

AU - Cerullo, Leonard

AU - Leestma, Jan

AU - Moskal, Joseph R.

N1 - Funding Information: The authors would like to gratefully acknowledge Mr. Kevin Cramer for his assistance in obtaining fresh tumor specimens. Work was supported in part by grants from the Illinois division of The American Cancer Society (H.Y.), The Buchanan Foundation (J.M.), The Brach Foundation (J.M.), and The Falk Foundation (J.M.). Copyright: Copyright 2015 Elsevier B.V., All rights reserved.

PY - 1997/4/25

Y1 - 1997/4/25

N2 - CMP-NeuAc: Galβ1,3(4)GlcNAc α2,3-sialyltransferase (α2,3-ST) mRNA was expressed in human glioma specimens, human fetal astrocytes, and a panel of brain tumor cell lines. Maackia amurensis agglutinin staining revealed the presence of α2,3-linked sialic acids on glioma cell surfaces and extracellular matrices whereas normal human adult astrocytes were negative. Increased expression of α2,3-linked glycoprotein sialylation may play a role in glial tumorigenesis.

AB - CMP-NeuAc: Galβ1,3(4)GlcNAc α2,3-sialyltransferase (α2,3-ST) mRNA was expressed in human glioma specimens, human fetal astrocytes, and a panel of brain tumor cell lines. Maackia amurensis agglutinin staining revealed the presence of α2,3-linked sialic acids on glioma cell surfaces and extracellular matrices whereas normal human adult astrocytes were negative. Increased expression of α2,3-linked glycoprotein sialylation may play a role in glial tumorigenesis.

KW - brain tumor

KW - glioma

KW - glycoprotein

KW - sialic acid

KW - sialyltransferase

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U2 - 10.1016/S0006-8993(97)00241-2

DO - 10.1016/S0006-8993(97)00241-2

M3 - Article

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AN - SCOPUS:0030611702

SN - 0006-8993

VL - 755

SP - 175

EP - 179

JO - Brain research

JF - Brain research

IS - 1

ER -

α2,3-Sialyltransferase mRNA and α2,3-linked glycoprotein sialylation are increased in malignant gliomas

Abstract

Keywords

ASJC Scopus subject areas

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