α2,3-Sialyltransferase mRNA and α2,3-linked glycoprotein sialylation are increased in malignant gliomas

Hirotaka Yamamoto, Tasuku Saito, Yoichi Kaneko, Donna Kersey, Voon Wee Yong, Eric G. Bremer, Edward Mkrdichian, Leonard Cerullo, Jan Leestma, Joseph R. Moskal*

*Corresponding author for this work

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

CMP-NeuAc: Galβ1,3(4)GlcNAc α2,3-sialyltransferase (α2,3-ST) mRNA was expressed in human glioma specimens, human fetal astrocytes, and a panel of brain tumor cell lines. Maackia amurensis agglutinin staining revealed the presence of α2,3-linked sialic acids on glioma cell surfaces and extracellular matrices whereas normal human adult astrocytes were negative. Increased expression of α2,3-linked glycoprotein sialylation may play a role in glial tumorigenesis.

Original languageEnglish (US)
Pages (from-to)175-179
Number of pages5
JournalBrain Research
Volume755
Issue number1
DOIs
StatePublished - Apr 25 1997

Keywords

  • brain tumor
  • glioma
  • glycoprotein
  • sialic acid
  • sialyltransferase

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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    Yamamoto, H., Saito, T., Kaneko, Y., Kersey, D., Yong, V. W., Bremer, E. G., Mkrdichian, E., Cerullo, L., Leestma, J., & Moskal, J. R. (1997). α2,3-Sialyltransferase mRNA and α2,3-linked glycoprotein sialylation are increased in malignant gliomas. Brain Research, 755(1), 175-179. https://doi.org/10.1016/S0006-8993(97)00241-2