αKlotho: FGF23 coreceptor and FGF23-regulating hormone

Harald Jüppner*, Myles Wolf

*Corresponding author for this work

Research output: Contribution to journalComment/debate

15 Scopus citations

Abstract

Low levels of phosphate can disrupt bone ossification and predispose to fractures. FGF23 is one of the major determinants of phosphate homeostasis, acting to increase urinary phosphate excretion. However, the regulation of FGF23 is incompletely understood. In this issue of the JCI, Smith et al. show that the cleaved form of αKlotho, the membrane-bound form of which is an FGF23 coreceptor, serves as a novel endocrine regulator of phosphate homeostasis, capable of inducing FGF23 production in osteocytes.

Original languageEnglish (US)
Pages (from-to)4336-4339
Number of pages4
JournalJournal of Clinical Investigation
Volume122
Issue number12
DOIs
StatePublished - Dec 3 2012

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'αKlotho: FGF23 coreceptor and FGF23-regulating hormone'. Together they form a unique fingerprint.

  • Cite this