α2-adrenergic receptors in platelet membranes of depressed patients: No change in number of 3H-yohimbine affinity

Makoto Daiguji*, Herbert Y. Meltzer, Ching Tong, David C. U'Prichard, Michael Young, Howard Kravitz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

The α2-adrenergic receptor density in platelet membranes from normal controls and depressed patients was studied using 3H-yohimbine, a potent α2-adrenergic antagonist, as a radioligand. The KD values of 3H-yohimbine in control and depressed patient samples were 0.92±0.07 nM and 0.97±0.06 nM, respectively. The Bmax values of controls and depressed patients were 240±19 fmoles/mg protein (128±13 receptor platelet, R/PL) and 204±20 fmoles/mg protein (139±14 R/L), respectively. There were no significant differences between the KD and Bmax values of the two groups.

Original languageEnglish (US)
Pages (from-to)2059-2064
Number of pages6
JournalLife Sciences
Volume29
Issue number20
DOIs
StatePublished - Nov 16 1981

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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