TY - JOUR
T1 - α2-adrenergic receptors in platelet membranes of depressed patients
T2 - No change in number of 3H-yohimbine affinity
AU - Daiguji, Makoto
AU - Meltzer, Herbert Y.
AU - Tong, Ching
AU - U'Prichard, David C.
AU - Young, Michael
AU - Kravitz, Howard
PY - 1981/11/16
Y1 - 1981/11/16
N2 - The α2-adrenergic receptor density in platelet membranes from normal controls and depressed patients was studied using 3H-yohimbine, a potent α2-adrenergic antagonist, as a radioligand. The KD values of 3H-yohimbine in control and depressed patient samples were 0.92±0.07 nM and 0.97±0.06 nM, respectively. The Bmax values of controls and depressed patients were 240±19 fmoles/mg protein (128±13 receptor platelet, R/PL) and 204±20 fmoles/mg protein (139±14 R/L), respectively. There were no significant differences between the KD and Bmax values of the two groups.
AB - The α2-adrenergic receptor density in platelet membranes from normal controls and depressed patients was studied using 3H-yohimbine, a potent α2-adrenergic antagonist, as a radioligand. The KD values of 3H-yohimbine in control and depressed patient samples were 0.92±0.07 nM and 0.97±0.06 nM, respectively. The Bmax values of controls and depressed patients were 240±19 fmoles/mg protein (128±13 receptor platelet, R/PL) and 204±20 fmoles/mg protein (139±14 R/L), respectively. There were no significant differences between the KD and Bmax values of the two groups.
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U2 - 10.1016/0024-3205(81)90662-7
DO - 10.1016/0024-3205(81)90662-7
M3 - Article
C2 - 6273681
AN - SCOPUS:0019850311
SN - 0024-3205
VL - 29
SP - 2059
EP - 2064
JO - Life Sciences
JF - Life Sciences
IS - 20
ER -