αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family

Sergio E. Chiarella, Erik E. Rabin, Lorena A. Ostilla, Annette S. Flozak, Cara J. Gottardi*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

α-Catenins are actin-filament binding proteins and critical subunits of the cadherin-catenin cell-cell adhesive complex. They are found in nominally-defined epithelial (E), neural (N), and testis (T) forms transcribed from three distinct genes. While most of α-catenin research has focused on the developmentally essential founding member, αE-catenin, this review discusses recent studies on αT-catenin (CTNNA3), a developmentally dispensable isoform that is emerging as relevant to cardiac, allergic and neurological diseases.

Original languageEnglish (US)
Article numbere1463896
JournalTissue Barriers
Volume6
Issue number2
DOIs
StatePublished - Apr 3 2018

Keywords

  • Biology of epithelial barriers
  • Desmosomes
  • adherens junctions
  • asthma
  • cadherins
  • cardiomyopathy
  • catenins, actin
  • cell-cell adhesion
  • neurological
  • signaling

ASJC Scopus subject areas

  • Biochemistry
  • Histology
  • Cell Biology

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