αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family

Sergio E. Chiarella; Erik E. Rabin; Lorena A. Ostilla; Annette S. Flozak; Cara J. Gottardi

doi:10.1080/21688370.2018.1463896

αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family

Sergio E. Chiarella, Erik E. Rabin, Lorena A. Ostilla, Annette S. Flozak, Cara J. Gottardi^*

^*Corresponding author for this work

Medicine, Pulmonary Division

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

α-Catenins are actin-filament binding proteins and critical subunits of the cadherin-catenin cell-cell adhesive complex. They are found in nominally-defined epithelial (E), neural (N), and testis (T) forms transcribed from three distinct genes. While most of α-catenin research has focused on the developmentally essential founding member, αE-catenin, this review discusses recent studies on αT-catenin (CTNNA3), a developmentally dispensable isoform that is emerging as relevant to cardiac, allergic and neurological diseases.

Original language	English (US)
Article number	e1463896
Journal	Tissue Barriers
Volume	6
Issue number	2
DOIs	https://doi.org/10.1080/21688370.2018.1463896
State	Published - Apr 3 2018

Keywords

Biology of epithelial barriers
Desmosomes
adherens junctions
asthma
cadherins
cardiomyopathy
catenins, actin
cell-cell adhesion
neurological
signaling

ASJC Scopus subject areas

Biochemistry
Cell Biology
Histology

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10.1080/21688370.2018.1463896

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title = "αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family",

abstract = "α-Catenins are actin-filament binding proteins and critical subunits of the cadherin-catenin cell-cell adhesive complex. They are found in nominally-defined epithelial (E), neural (N), and testis (T) forms transcribed from three distinct genes. While most of α-catenin research has focused on the developmentally essential founding member, αE-catenin, this review discusses recent studies on αT-catenin (CTNNA3), a developmentally dispensable isoform that is emerging as relevant to cardiac, allergic and neurological diseases.",

keywords = "Biology of epithelial barriers, Desmosomes, adherens junctions, asthma, cadherins, cardiomyopathy, catenins, actin, cell-cell adhesion, neurological, signaling",

author = "Chiarella, {Sergio E.} and Rabin, {Erik E.} and Ostilla, {Lorena A.} and Flozak, {Annette S.} and Gottardi, {Cara J.}",

note = "Funding Information: S.E.C. and E.E.R. were supported by the Northwestern University Allergy Immunology Research Program (NUAIR) T32AI083216 and C.J.G. by NIHL134800. Publisher Copyright: {\textcopyright} 2018, {\textcopyright} 2018 The Author(s). Published with license by Taylor & Francis. {\textcopyright} 2018, {\textcopyright} Sergio E. Chiarella, Erik E. Rabin, Lorena A. Ostilla, Annette S. Flozak, and Cara J. Gottardi.",

year = "2018",

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T2 - A developmentally dispensable, disease-linked member of the α-catenin family

AU - Chiarella, Sergio E.

AU - Rabin, Erik E.

AU - Ostilla, Lorena A.

AU - Flozak, Annette S.

AU - Gottardi, Cara J.

N1 - Funding Information: S.E.C. and E.E.R. were supported by the Northwestern University Allergy Immunology Research Program (NUAIR) T32AI083216 and C.J.G. by NIHL134800. Publisher Copyright: © 2018, © 2018 The Author(s). Published with license by Taylor & Francis. © 2018, © Sergio E. Chiarella, Erik E. Rabin, Lorena A. Ostilla, Annette S. Flozak, and Cara J. Gottardi.

PY - 2018/4/3

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N2 - α-Catenins are actin-filament binding proteins and critical subunits of the cadherin-catenin cell-cell adhesive complex. They are found in nominally-defined epithelial (E), neural (N), and testis (T) forms transcribed from three distinct genes. While most of α-catenin research has focused on the developmentally essential founding member, αE-catenin, this review discusses recent studies on αT-catenin (CTNNA3), a developmentally dispensable isoform that is emerging as relevant to cardiac, allergic and neurological diseases.

AB - α-Catenins are actin-filament binding proteins and critical subunits of the cadherin-catenin cell-cell adhesive complex. They are found in nominally-defined epithelial (E), neural (N), and testis (T) forms transcribed from three distinct genes. While most of α-catenin research has focused on the developmentally essential founding member, αE-catenin, this review discusses recent studies on αT-catenin (CTNNA3), a developmentally dispensable isoform that is emerging as relevant to cardiac, allergic and neurological diseases.

KW - Biology of epithelial barriers

KW - Desmosomes

KW - adherens junctions

KW - asthma

KW - cadherins

KW - cardiomyopathy

KW - catenins, actin

KW - cell-cell adhesion

KW - neurological

KW - signaling

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ER -

αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family

Abstract

Keywords

ASJC Scopus subject areas

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