TY - JOUR
T1 - β-Adrenergic receptor binding in frontal cortex of suicide victims
AU - Stockmeier, Craig A.
AU - Meltzer, Herbert Y.
N1 - Funding Information:
This work was supported by Clinical Research Center Grant MH 41684 and by a USPHS Research Career Scientist Award MH 47808 to HYM. The tectmical assistance of J. Joarme DiCarlo, the=t yping assistance of Lee Mason, a;,d the assistance of Jar-Chi Lee in statistical analyses are gratefully acknowledged.
PY - 1991/1/15
Y1 - 1991/1/15
N2 - The high-affinity binding of the β-adrenergic receptor antagonist, [3H]dihydroalprenolol, was measured in homogenates of frontal cortex (Brodmann's areas 8 and 9) of suicide victims and matched controls. Suicides were classified as violent if gunshot, hanging, or jumping was the cause of death and as nonviolent if carbon monoxide poisoning or drug overdose was the cause of death. No significant differences were found between controls and nonviolent or violent suicide victims with regard to the number of β-adrenergic receptors (Bmax), or the binding affinity (Kd) of the receptor. β-Adrenergic receptor binding was not significantly affected by sex, age, race, or postmortem interval. Serotonin-2 receptor binding (Bmax) in homogenates from the same tissue specimens was previously reported to be significantly increased in violent suicides (Arora and Meltzer 1989). In these sample groups, suicide by violent means appears to be associated with an increase in the number of serotonin-2, but not β-adrenergic, receptors in frontal cortex.
AB - The high-affinity binding of the β-adrenergic receptor antagonist, [3H]dihydroalprenolol, was measured in homogenates of frontal cortex (Brodmann's areas 8 and 9) of suicide victims and matched controls. Suicides were classified as violent if gunshot, hanging, or jumping was the cause of death and as nonviolent if carbon monoxide poisoning or drug overdose was the cause of death. No significant differences were found between controls and nonviolent or violent suicide victims with regard to the number of β-adrenergic receptors (Bmax), or the binding affinity (Kd) of the receptor. β-Adrenergic receptor binding was not significantly affected by sex, age, race, or postmortem interval. Serotonin-2 receptor binding (Bmax) in homogenates from the same tissue specimens was previously reported to be significantly increased in violent suicides (Arora and Meltzer 1989). In these sample groups, suicide by violent means appears to be associated with an increase in the number of serotonin-2, but not β-adrenergic, receptors in frontal cortex.
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U2 - 10.1016/0006-3223(91)90047-P
DO - 10.1016/0006-3223(91)90047-P
M3 - Article
C2 - 1847309
AN - SCOPUS:0025964286
SN - 0006-3223
VL - 29
SP - 183
EP - 191
JO - Biological psychiatry
JF - Biological psychiatry
IS - 2
ER -