TY - JOUR
T1 - β-Amyloid and the pathogenesis of alzheimer's disease
AU - Yankner, Bruce A.
AU - Mesulam, M. Marsel
PY - 1991/12/26
Y1 - 1991/12/26
N2 - SIXTY to 80 percent of cases of dementia among persons over the age of 65 are caused by Alzheimer's disease. Most of the remainder are caused by cerebrovascular disease with multiple infarcts, and a smaller proportion are due to tumors, infections (e.g., infection with the human immunodeficiency virus), metabolic disorders, depression (“pseudodementia”), and the less common neurodegenerative diseases, including Pick's disease, progressive supranuclear palsy, and Huntington's disease.1 2 3 Alzheimer's disease has been estimated to afflict 5 to 11 percent of the population over the age of 65 and as much as 47 percent of the population over the age of 85.
AB - SIXTY to 80 percent of cases of dementia among persons over the age of 65 are caused by Alzheimer's disease. Most of the remainder are caused by cerebrovascular disease with multiple infarcts, and a smaller proportion are due to tumors, infections (e.g., infection with the human immunodeficiency virus), metabolic disorders, depression (“pseudodementia”), and the less common neurodegenerative diseases, including Pick's disease, progressive supranuclear palsy, and Huntington's disease.1 2 3 Alzheimer's disease has been estimated to afflict 5 to 11 percent of the population over the age of 65 and as much as 47 percent of the population over the age of 85.
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U2 - 10.1056/NEJM199112263252605
DO - 10.1056/NEJM199112263252605
M3 - Review article
C2 - 1961223
AN - SCOPUS:0026432318
SN - 0028-4793
VL - 325
SP - 1849
EP - 1857
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 26
ER -
