β-Carotene transport in human lipoproteins. Comparisons with a-tocopherol

Maret G. Traber*, Seth R. Diamond, Jerome C. Lane, Rachel I. Brody, Herbert J. Kayden

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

The purpose of this study was to investigate the temporal relationships of the transport of β-carotene in human lipoproteins. We administered 60 mg β-carotene with breakfast to nine fasting subjects, then blood samples were collected at intervals of up to 75 h, lipoproteins were isolated, and β-carotene was quantitated. β-Carotene concentrations in chylomicrons and very low density lipoproteins (VLDL) peaked at 6 and 9 h, respectively. Nonetheless, at all time points the majority of plasma β-carotene was contained in low density lipoproteins (LDL), while high density lipoproteins (HDL) carried a smaller portion (at 24 h, 73±8% in LDL as compared with 23±5% in HDL). In three subjects, transport of β-carotene was compred with the results of earlier studies on the transport of stereoisomers of α-tocopherol. Unlike plasma RRR-α-tocopherol concentrations, which are maintained by the preferential incorporation of RRR-α-tocopherol into VLDL by the liver, β-carotene increased and decreased in VLDL similarly to SRR-α-tocopherol, a stereoisomer whose concentrations are not maintained in plasma. In conclusion, β-carotene is primarily transported in the plasma in LDL, but its incorporation by the liver into lipoproteins does not appear to be enhanced.

Original languageEnglish (US)
Pages (from-to)665-669
Number of pages5
JournalLipids
Volume29
Issue number10
DOIs
StatePublished - Oct 1994

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Cell Biology

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