β-catenin signaling: A novel mediator of fibrosis and potential therapeutic target

Anna P. Lam*, Cara J. Gottardi

*Corresponding author for this work

Research output: Contribution to journalReview article

109 Scopus citations

Abstract

Purpose of review: The Wnt/β-catenin signaling pathway plays a critical role in development and adult tissue homeostasis. Recent investigations implicate Wnt/β-catenin signaling in abnormal wound repair and fibrogenesis. The purpose of this review is to highlight recent key studies that support a role for Wnt/β-catenin signaling in fibrosis. Recent findings: Studies of patients with fibrotic diseases have demonstrated changes in components of the Wnt/β-catenin pathway. In animal models, perturbations in Wnt/β-catenin signaling appear to aggravate or ameliorate markers of injury and fibrosis in a variety of different tissues. Studies also suggest that fibroblasts from different tissue sources may have markedly divergent responses to Wnt/β-catenin signaling. Cross-talk between Wnt/β-catenin and transforming growth factor-b pathways is complex and contextdependent, and may promote fibrogenesis through coregulation of fibrogenic gene targets. High throughput screening has identified several novel chemical inhibitors of Wnt/β-catenin signaling that may be of therapeutic potential.Summary: Wnt/β-catenin signaling appears important in normal wound healing and its sustained activation is associated with fibrogenesis. The mechanism by which Wnt/β-catenin signaling may modify the response to injury is cell-type and context-dependent. Better understanding of this signaling pathway may provide a promising new therapeutic approach for human fibrotic diseases.

Original languageEnglish (US)
Pages (from-to)562-567
Number of pages6
JournalCurrent opinion in rheumatology
Volume23
Issue number6
DOIs
StatePublished - Nov 2011

Keywords

  • Fibrosis
  • Wnt
  • Wound repair
  • β-catenin

ASJC Scopus subject areas

  • Rheumatology

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