β-Catenin/TCF/LEF regulate expression of the short form human Cripto-1

Shin Hamada; Kazuhide Watanabe; Morihisa Hirota; Caterina Bianco; Luigi Strizzi; Mario Mancino; Monica Gonzales; David S. Salomon

doi:10.1016/j.bbrc.2007.01.143

β-Catenin/TCF/LEF regulate expression of the short form human Cripto-1

Shin Hamada, Kazuhide Watanabe, Morihisa Hirota, Caterina Bianco, Luigi Strizzi, Mario Mancino, Monica Gonzales, David S. Salomon^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

The human gene Teratocarcinoma-derived growth factor 1 (TDGF1)/Cripto-1/CR-1 which is expressed in a wide variety of human carcinomas is a member of the EGF-cripto FRL1 cryptic (EGF-CFC) gene family. A majority of human colorectal tumors and hepatomas are known to possess a constitutively active canonical Wnt/β-catenin/TCF signaling pathway, also express CR-1. Expression of a short form of CR-1 mRNA in colon carcinoma and hepatoma cell lines suggests that there may be differential regulation of CR-1 expression by the canonical Wnt signaling pathway in colon cancer as well as hepatoma cell lines. The present study demonstrates a direct transcriptional regulation of the short form CR-1 expression by the canonical Wnt signaling pathway through an intronic-exonic enhancer element, containing three tandem TCF/LEF binding sites within the CR-1 gene.

Original language	English (US)
Pages (from-to)	240-244
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	355
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2007.01.143
State	Published - Mar 30 2007
Externally published	Yes

Keywords

Cripto-1
Wnt
β-Catenin

ASJC Scopus subject areas

Molecular Biology
Biophysics
Biochemistry
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbrc.2007.01.143

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title = "β-Catenin/TCF/LEF regulate expression of the short form human Cripto-1",

abstract = "The human gene Teratocarcinoma-derived growth factor 1 (TDGF1)/Cripto-1/CR-1 which is expressed in a wide variety of human carcinomas is a member of the EGF-cripto FRL1 cryptic (EGF-CFC) gene family. A majority of human colorectal tumors and hepatomas are known to possess a constitutively active canonical Wnt/β-catenin/TCF signaling pathway, also express CR-1. Expression of a short form of CR-1 mRNA in colon carcinoma and hepatoma cell lines suggests that there may be differential regulation of CR-1 expression by the canonical Wnt signaling pathway in colon cancer as well as hepatoma cell lines. The present study demonstrates a direct transcriptional regulation of the short form CR-1 expression by the canonical Wnt signaling pathway through an intronic-exonic enhancer element, containing three tandem TCF/LEF binding sites within the CR-1 gene.",

keywords = "Cripto-1, Wnt, β-Catenin",

author = "Shin Hamada and Kazuhide Watanabe and Morihisa Hirota and Caterina Bianco and Luigi Strizzi and Mario Mancino and Monica Gonzales and Salomon, {David S.}",

year = "2007",

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day = "30",

doi = "10.1016/j.bbrc.2007.01.143",

language = "English (US)",

volume = "355",

pages = "240--244",

journal = "Biochemical and Biophysical Research Communications",

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publisher = "Elsevier B.V.",

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}

TY - JOUR

T1 - β-Catenin/TCF/LEF regulate expression of the short form human Cripto-1

AU - Hamada, Shin

AU - Watanabe, Kazuhide

AU - Hirota, Morihisa

AU - Bianco, Caterina

AU - Strizzi, Luigi

AU - Mancino, Mario

AU - Gonzales, Monica

AU - Salomon, David S.

PY - 2007/3/30

Y1 - 2007/3/30

N2 - The human gene Teratocarcinoma-derived growth factor 1 (TDGF1)/Cripto-1/CR-1 which is expressed in a wide variety of human carcinomas is a member of the EGF-cripto FRL1 cryptic (EGF-CFC) gene family. A majority of human colorectal tumors and hepatomas are known to possess a constitutively active canonical Wnt/β-catenin/TCF signaling pathway, also express CR-1. Expression of a short form of CR-1 mRNA in colon carcinoma and hepatoma cell lines suggests that there may be differential regulation of CR-1 expression by the canonical Wnt signaling pathway in colon cancer as well as hepatoma cell lines. The present study demonstrates a direct transcriptional regulation of the short form CR-1 expression by the canonical Wnt signaling pathway through an intronic-exonic enhancer element, containing three tandem TCF/LEF binding sites within the CR-1 gene.

AB - The human gene Teratocarcinoma-derived growth factor 1 (TDGF1)/Cripto-1/CR-1 which is expressed in a wide variety of human carcinomas is a member of the EGF-cripto FRL1 cryptic (EGF-CFC) gene family. A majority of human colorectal tumors and hepatomas are known to possess a constitutively active canonical Wnt/β-catenin/TCF signaling pathway, also express CR-1. Expression of a short form of CR-1 mRNA in colon carcinoma and hepatoma cell lines suggests that there may be differential regulation of CR-1 expression by the canonical Wnt signaling pathway in colon cancer as well as hepatoma cell lines. The present study demonstrates a direct transcriptional regulation of the short form CR-1 expression by the canonical Wnt signaling pathway through an intronic-exonic enhancer element, containing three tandem TCF/LEF binding sites within the CR-1 gene.

KW - Cripto-1

KW - Wnt

KW - β-Catenin

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DO - 10.1016/j.bbrc.2007.01.143

M3 - Article

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AN - SCOPUS:33847016833

SN - 0006-291X

VL - 355

SP - 240

EP - 244

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 1

ER -

β-Catenin/TCF/LEF regulate expression of the short form human Cripto-1

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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