β-Methyl carboline, a benzodiazepine inverse agonist, attenuates the effect of triazolam on the circadian rhythm of locomotor activity

R. D. Smith*, F. W. Turek

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The benzodiazepine triazolam, the benzodiazepine inverse agonist, β-methyl carboline (β-CCM) or both, were administered to adult male hamsters under conditions of constant light. When given alone, triazolam induced phase advances in the circadian activity rhythm of about 90 min, while β-CCM when given alone, had no effect on phase of the activity rhythm. However, when triazolam and β-CCM were given at the same time, the magnitude of the phase advances induced by triazolam were attenuated to about 30 min. These data, in conjunction with previous results, provide pharmacological evidence for a GABAergic system involved in the regulation of a central circadian pacemaker.

Original languageEnglish (US)
Pages (from-to)334-337
Number of pages4
JournalExperientia
Volume45
Issue number4
DOIs
StatePublished - Apr 1989

Keywords

  • Benzodiazepine
  • circadian rhythm
  • gamma-aminobutyric acid
  • inverse agonist
  • suprachiasmatic nucleus
  • triazolam

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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