γδ T cell recognition of tumor Ig peptide

H. T. Kim, E. L. Nelson, C. Clayberger, M. Sanjanwala, J. Sklar, A. M. Krensky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Although γδ T cells have been postulated to act as a surveillance mechanism that eliminates transformed or otherwise damaged cells, little is known about tumor recognition by γδ T cells, including the Ags that are recognized and the molecules that present them. Previously, we described human γδ CTL that recognize the autologous B cell lymphoma. Here we report that these γδ CTL lyse heterologous cells transfected with the tumor Ig λ chain gene. Furthermore, the λ chain is recognized as processed peptide in an Id-specific manner. T cell recognition does not involve classical MHC molecules, but it could be blocked by Abs directed against the heat shock protein grp75. These findings show a specific γδ T cell response to a highly polymorphic Ag such as tumor Id and implicate heat shock protein as a molecule required for recognition.

Original languageEnglish (US)
Pages (from-to)1614-1623
Number of pages10
JournalJournal of Immunology
Volume154
Issue number4
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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