γδ T cells restrain extrathymic development of Foxp3+-inducible regulatory T cells via IFN-γ

Anabelle Visperas, Bo Shen, Booki Min*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Inducible Treg (iTreg) cells generated from Ag-stimulated naïve CD4+ T cells in the periphery play an important role in regulating immune responses. TGF-β is a key cytokine that promotes this conversion process; however, how this process is regulated in vivo remains unclear. Here, we report that γδ T cells play a crucial role in controlling iTreg generation and suppressor function. Ag-induced iTreg generation was significantly enhanced in C57BL/6 mice in the absence of γδ T cells. Inhibition of iTreg conversion was mediated by IFN-γ produced by activated γδ T cells but not by activated CD4+ T cells. BM chimera experiments further confirmed γδ-derived IFN-γ-dependent mechanism in regulating iTreg generation in vivo. Lastly, human peripheral blood γδ T cells also interfere with iTreg conversion via IFN-γ. Our results suggest a novel function of γδ T cells in limiting the generation of iTreg cells, potentially balancing immunity and tolerance.

Original languageEnglish (US)
Pages (from-to)2448-2456
Number of pages9
JournalEuropean Journal of Immunology
Volume44
Issue number8
DOIs
StatePublished - Aug 2014
Externally publishedYes

Keywords

  • IFN-γ
  • Inflammation
  • Intestine
  • ITreg cells
  • Oral tolerance
  • Regulatory T cells
  • γδ T cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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