γ-glutamyltranspeptidase-negative phenotypic property of preneoplastic and neoplastic liver lesions induced by ciprofibrate does not change following 2-acetylaminofluorene administration

A. V. Yeldandi*, V. Subbarao, A. Rajan, J. K. Reddy, M. S. Rao

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Preneoplastic and neoplastic lesions induced by peroxisome proliferators in the livers of rats and mice do not express -γ-glutamyltranspeptidase (GGT). Previous studies have shown that the absence of GGT is not due to the toxic effect of peroxisome proliferators or due to the presence of inactive enzyme. The present experiment was designed to examine whether the GGT-negative property of these lesions is stable and irreversible or whether these lesions can be modulated to express GGT by 2-acetylaminofluorene (AAF). Hepatic lesions were induced in F-344 rats by feeding ciprofibrate (0.025%) in diet for 60 or 84 weeks. These rats were then administered AAF in diet (0.02%) for 5 weeks and the altered areas (AAs), neoplastic nodules (NNs) and hepatocellular carcinomas were analyzed for the expression of GGT. Ninety per cent of carcinomas, 90-100% of NNs and >60% AAs were negative for GGT following AAF treatment. These results are very similar to the phenotypic features observed in the livers of rats treated with ciprofibrate alone. The results of this study suggest that the GGT-negative property of ciprofibrate-induced lesions is stable and not modulatable by AAF.

Original languageEnglish (US)
Pages (from-to)797-799
Number of pages3
JournalCarcinogenesis
Volume10
Issue number4
DOIs
StatePublished - Apr 1 1989

ASJC Scopus subject areas

  • Cancer Research

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