γ Interferon induced by S. aureus protein A augments natural killing and   ADCC

William J. Catalona; Timothy L. Ratliff; Robert E. McCool

doi:10.1038/291077a0

γ Interferon induced by S. aureus protein A augments natural killing and ADCC

William J. Catalona^*, Timothy L. Ratliff, Robert E. McCool

^*Corresponding author for this work

Urology

Research output: Contribution to journal › Article › peer-review

99 Scopus citations

Abstract

Staphylococcus aureus produces a protein identified as protein A (SpA) with a molecular weight of 41,000 (ref. 1) which binds to the Fc region of many types of mammalian IgG², activates complement³, blocks opsonins⁴ and is both chemotactic⁵ and mitogenic ^6,7. SpA has been used for various immunological purposes including removal of immune complexes⁸, arming effector cells with antibody⁹, distinguishing between antibody-dependent cell-mediated cytotoxicity (ADCC) and natural killing (NK)¹⁰, and exerting anti-tumour activity¹¹. We have now demonstrated that SpA induces the production of γ interferon (IFN-γ) in nonadherent, T lymphocyte-depleted (E^-), Fc receptor-bearing (FcR⁺) human peripheral blood lymphocytes. Our data also suggest that IFN-γ is a potent stimulator of both NK and ADCC activity.

Original language	English (US)
Pages (from-to)	77-79
Number of pages	3
Journal	Nature
Volume	291
Issue number	5810
DOIs	https://doi.org/10.1038/291077a0
State	Published - Dec 1 1981

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title = "γ Interferon induced by S. aureus protein A augments natural killing and ADCC",

abstract = "Staphylococcus aureus produces a protein identified as protein A (SpA) with a molecular weight of 41,000 (ref. 1) which binds to the Fc region of many types of mammalian IgG2, activates complement3, blocks opsonins4 and is both chemotactic5 and mitogenic 6,7. SpA has been used for various immunological purposes including removal of immune complexes8, arming effector cells with antibody9, distinguishing between antibody-dependent cell-mediated cytotoxicity (ADCC) and natural killing (NK)10, and exerting anti-tumour activity11. We have now demonstrated that SpA induces the production of γ interferon (IFN-γ) in nonadherent, T lymphocyte-depleted (E-), Fc receptor-bearing (FcR+) human peripheral blood lymphocytes. Our data also suggest that IFN-γ is a potent stimulator of both NK and ADCC activity.",

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AU - Catalona, William J.

AU - Ratliff, Timothy L.

AU - McCool, Robert E.

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N2 - Staphylococcus aureus produces a protein identified as protein A (SpA) with a molecular weight of 41,000 (ref. 1) which binds to the Fc region of many types of mammalian IgG2, activates complement3, blocks opsonins4 and is both chemotactic5 and mitogenic 6,7. SpA has been used for various immunological purposes including removal of immune complexes8, arming effector cells with antibody9, distinguishing between antibody-dependent cell-mediated cytotoxicity (ADCC) and natural killing (NK)10, and exerting anti-tumour activity11. We have now demonstrated that SpA induces the production of γ interferon (IFN-γ) in nonadherent, T lymphocyte-depleted (E-), Fc receptor-bearing (FcR+) human peripheral blood lymphocytes. Our data also suggest that IFN-γ is a potent stimulator of both NK and ADCC activity.

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