π-Extended Donor–Acceptor Porphyrins and Metalloporphyrins for Antimicrobial Photodynamic Inactivation

Anzhela Galstyan; Yogesh Kumar Maurya; Halina Zhylitskaya; Youn Jue Bae; Yi Lin Wu; Michael R. Wasielewski; Tadeusz Lis; Ulrich Dobrindt; Marcin Stępień

doi:10.1002/chem.201905372

π-Extended Donor–Acceptor Porphyrins and Metalloporphyrins for Antimicrobial Photodynamic Inactivation

Anzhela Galstyan^*, Yogesh Kumar Maurya, Halina Zhylitskaya, Youn Jue Bae, Yi Lin Wu, Michael R. Wasielewski, Tadeusz Lis, Ulrich Dobrindt, Marcin Stępień

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Free base, zinc and palladium π-extended porphyrins containing fused naphthalenediamide units were employed as photosensitizers in antimicrobial photodynamic therapy (aPDT). Their efficacy, assessed by photophysical and in vitro photobiological studies on Gram-positive bacteria, was found to depend on metal coordination, showing a dramatic enhancement of photosensitizing activity for the palladium complex.

Original language	English (US)
Pages (from-to)	8262-8266
Number of pages	5
Journal	Chemistry - A European Journal
Volume	26
Issue number	37
DOIs	https://doi.org/10.1002/chem.201905372
State	Published - Jul 2 2020

Keywords

antimicrobial
photosensitizers
singlet oxygen
triplet state
π-extended porphyrins

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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10.1002/chem.201905372

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@article{57b6322cff2945bfae2912883a62ef6e,

title = "π-Extended Donor–Acceptor Porphyrins and Metalloporphyrins for Antimicrobial Photodynamic Inactivation",

abstract = "Free base, zinc and palladium π-extended porphyrins containing fused naphthalenediamide units were employed as photosensitizers in antimicrobial photodynamic therapy (aPDT). Their efficacy, assessed by photophysical and in vitro photobiological studies on Gram-positive bacteria, was found to depend on metal coordination, showing a dramatic enhancement of photosensitizing activity for the palladium complex.",

keywords = "antimicrobial, photosensitizers, singlet oxygen, triplet state, π-extended porphyrins",

author = "Anzhela Galstyan and Maurya, {Yogesh Kumar} and Halina Zhylitskaya and Bae, {Youn Jue} and Wu, {Yi Lin} and Wasielewski, {Michael R.} and Tadeusz Lis and Ulrich Dobrindt and Marcin St{\c e}pie{\'n}",

note = "Funding Information: This work was supported by the Foundation for Polish Science (TEAM POIR.04.04.00‐00‐5BF1/17‐00, to M.S.), U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences under Award DE‐FG02‐99ER14999 (M.R.W.), German Research Foundation (DFG GA 2362/2‐1, to A.G.), and Fonds der Chemischen Industrie (to A.G.). Publisher Copyright: {\textcopyright} 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.",

year = "2020",

month = jul,

day = "2",

doi = "10.1002/chem.201905372",

language = "English (US)",

volume = "26",

pages = "8262--8266",

journal = "Chemistry - A European Journal",

issn = "0947-6539",

publisher = "Wiley-VCH Verlag",

number = "37",

}

TY - JOUR

T1 - π-Extended Donor–Acceptor Porphyrins and Metalloporphyrins for Antimicrobial Photodynamic Inactivation

AU - Galstyan, Anzhela

AU - Maurya, Yogesh Kumar

AU - Zhylitskaya, Halina

AU - Bae, Youn Jue

AU - Wu, Yi Lin

AU - Wasielewski, Michael R.

AU - Lis, Tadeusz

AU - Dobrindt, Ulrich

AU - Stępień, Marcin

N1 - Funding Information: This work was supported by the Foundation for Polish Science (TEAM POIR.04.04.00‐00‐5BF1/17‐00, to M.S.), U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences under Award DE‐FG02‐99ER14999 (M.R.W.), German Research Foundation (DFG GA 2362/2‐1, to A.G.), and Fonds der Chemischen Industrie (to A.G.). Publisher Copyright: © 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

PY - 2020/7/2

Y1 - 2020/7/2

N2 - Free base, zinc and palladium π-extended porphyrins containing fused naphthalenediamide units were employed as photosensitizers in antimicrobial photodynamic therapy (aPDT). Their efficacy, assessed by photophysical and in vitro photobiological studies on Gram-positive bacteria, was found to depend on metal coordination, showing a dramatic enhancement of photosensitizing activity for the palladium complex.

AB - Free base, zinc and palladium π-extended porphyrins containing fused naphthalenediamide units were employed as photosensitizers in antimicrobial photodynamic therapy (aPDT). Their efficacy, assessed by photophysical and in vitro photobiological studies on Gram-positive bacteria, was found to depend on metal coordination, showing a dramatic enhancement of photosensitizing activity for the palladium complex.

KW - antimicrobial

KW - photosensitizers

KW - singlet oxygen

KW - triplet state

KW - π-extended porphyrins

UR - http://www.scopus.com/inward/record.url?scp=85085971838&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85085971838&partnerID=8YFLogxK

U2 - 10.1002/chem.201905372

DO - 10.1002/chem.201905372

M3 - Article

C2 - 31968144

AN - SCOPUS:85085971838

SN - 0947-6539

VL - 26

SP - 8262

EP - 8266

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 37

ER -

π-Extended Donor–Acceptor Porphyrins and Metalloporphyrins for Antimicrobial Photodynamic Inactivation

Abstract

Keywords

ASJC Scopus subject areas

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CCDC 1935942: Experimental Crystal Structure Determination

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π-Extended Donor–Acceptor Porphyrins and Metalloporphyrins for Antimicrobial Photodynamic Inactivation

Abstract

Keywords

ASJC Scopus subject areas

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CCDC 1935942: Experimental Crystal Structure Determination

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