活动性葡萄膜炎引起暂时性屈光度变化

AIM: To evaluate the impact of active uveitis on refractive error changes. METHODS: A prospective cohort study was conducted on 66 patients (88 eyes) with active uveitis. The subjects were classified based on the anatomical location of their disease activity as anterior, intermediate, posterior and pan-uveitis. Cycloplegic refraction was performed in both active and quiescent phases, and the results were compared. RESULTS: Spherical changes in active anterior non-granulomatous uveitis resulted in an average of -0.25 (0.77) D (95% CI: -0.5 to 0) shift toward myopia (P=0.039) and in active intermediate uveitis, an average of +0.39 (0.8) D (95% CI: 0.09-0.69) shift toward hyperopia (P=0.003). Spherical equivalent changes in active intermediate uveitis resulted in hyperopic shift [+0.43 (0.94) D, 95% CI: 0.08-0.79, P=0.005]. Cylinder had only significant changes in pan-uveitis [-0.3 (0.39) D, 95% CI: -0.58 to -0.02, P=0.043]. In multivariate analysis, we noted that course of disease activity (acute versus recurrent) and anatomical location of disease activity had statistically significant effects on spherical equivalent changes (P=0.003 and P=0.004, respectively). CONCLUSION: Active uveitis has a significant effect on the refractive status of the eye, the changes of which depend on the inflamed anatomical area.