1α,25-dihydroxyvitamin D3 nuclear receptors in the pituitary

Harris A. Gelbard*, Paula H. Stern, David C. U'Prichard

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Specific binding of 1α,25-dihydroxyvitamin D3 was found in nuclear and cytosol fractions of the bovine pituitary. For nuclear binding, the dissociation constant was 0.1 nanomole per liter, and maximum binding was 104 femtomoles per milligram of protein. In competition studies, 25-hydroxyvitamin D3 was 300 times weaker than 1α,25-dihydroxyvitamin D3. The existence of high-affinity sites supports a physiologic role for 1α,25-dihydroxyvitamin D3 in the pituitary.

Original languageEnglish (US)
Pages (from-to)1247-1249
Number of pages3
JournalScience
Volume209
Issue number4462
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • General

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