Administration of 1 methyl 4 piperidyl bis (p chlorophenoxy) acetate (SaH 42-348) at a dietary concentration of 0.15% for 3 wk, increased the activity of catalase in liver and kidney of male wild type (Cs(a) strain) mice. A marked increase in the activity of short chain carnitine acyltransferase in the liver was also noted. By electron microscopy, a remarkable increase in the number of peroxisomes (microbodies) was noted in the liver cells. A mild to moderate increase in number of peroxisomes in proximal convoluted tubular epithelium of the kidney was also seen. These studies demonstrate that SaH 42-348 is a potent hepatic peroxisome proliferator.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Jan 1 1975|
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)