1 Methyl 4 piperidyl bis(P chlorophenoxy) acetate: a new hypolipidemic peroxisome proliferator

J. K. Reddy, T. P. Krishnakantha, D. L. Azarnoff, D. E. Moody

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Administration of 1 methyl 4 piperidyl bis (p chlorophenoxy) acetate (SaH 42-348) at a dietary concentration of 0.15% for 3 wk, increased the activity of catalase in liver and kidney of male wild type (Cs(a) strain) mice. A marked increase in the activity of short chain carnitine acyltransferase in the liver was also noted. By electron microscopy, a remarkable increase in the number of peroxisomes (microbodies) was noted in the liver cells. A mild to moderate increase in number of peroxisomes in proximal convoluted tubular epithelium of the kidney was also seen. These studies demonstrate that SaH 42-348 is a potent hepatic peroxisome proliferator.

Original languageEnglish (US)
Pages (from-to)589-592
Number of pages4
JournalRES.COMMUN.CHEM.PATH.PHARMACOL.
Volume10
Issue number3
StatePublished - Jan 1 1975

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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