Abstract
While the vast majority of primary parenchymal tumors of the central nervous system are gliomas, there are a small but growing number of tumor types with neuronal differentiation. Some of the tumors in this category can have a pure neuronal differentiation pattern (e.g., gangliocytoma and central neurocytoma), while others have a mixed glial and neuronal phenotype (e.g., ganglioglioma and papillary glioneuronal tumor). Neuronal and glioneuronal tumors are recognized primarily by their clinical, radiologic, and histologic properties, but they also have characteristic immunohistochemical profiles and signature molecular genetic alterations. Most of these tumors in this category are circumscribed and have indolent clinical behavior compared to the diffusely infiltrative gliomas.
Original language | English (US) |
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Title of host publication | Practical Surgical Neuropathology |
Subtitle of host publication | A Diagnostic Approach A Volume in the Pattern Recognition Series |
Publisher | Elsevier Inc |
Pages | 183-217 |
Number of pages | 35 |
ISBN (Print) | 9780323449410 |
DOIs | |
State | Published - Jan 1 2018 |
Keywords
- Central neurocytoma
- Cerebellar liponeurocytoma
- Desmoplastic infantile astrocytoma/ganglioglioma
- Diffuse leptomeningeal glioneuronal tumor
- Dysembryoplastic neuroepithelial tumor
- Dysplastic gangliocytoma
- Gangliocytoma
- Ganglioglioma
- Hypothalamic hamartoma
- Lhermitte-Duclos disease
- Papillary glioneuronal tumor
- Rosette-forming glioneuronal tumor
ASJC Scopus subject areas
- General Medicine