TY - JOUR
T1 - 10-Second heart rate variability and cognitive function in old age
AU - Mahinrad, Simin
AU - Jukema, J. Wouter
AU - Van Heemst, Diana
AU - MacFarlane, Peter W.
AU - Clark, Elaine N.
AU - De Craen, Anton J.M.
AU - Sabayan, Behnam
N1 - Publisher Copyright:
© 2016 American Academy of Neurology.
PY - 2016/3/22
Y1 - 2016/3/22
N2 - Objective: To investigate the cross-sectional and longitudinal associations of 10-second heart rate variability (HRV) with various domains of cognitive function in older participants at risk of cardiovascular disease. Methods: We studied 3,583 participants, mean age of 75.0 years, who were enrolled in the Prospective Study of Pravastatin in the Elderly at Risk. From baseline 10-second ECGs, standard deviation of normal-to-normal intervals was calculated as the index of HRV. Four cognitive domains were assessed at baseline and repeated during a mean follow-up period of 3.2 years. Results: Lower HRV at baseline was associated with worse performance in reaction time (mean difference between low third vs high third of HRV 1.96 seconds, 95% confidence interval [CI] 0.20 to 3.71) and processing speed (-0.57 digits coded, 95% CI -1.09 to -0.05). During follow-up, participants with lower HRV had a steeper decline in processing speed (mean annual change between low third vs high third of HRV -0.16 digits coded, 95% CI -0.28 to -0.04). There was no difference in annual changes of reaction time or immediate and delayed memory among HRV thirds during follow-up. All these associations remained unchanged after adjustment for medications, cardiovascular risk factors, and comorbidities. Conclusions: Participants with lower 10-second HRV have worse performance in reaction time and processing speed and experience steeper decline in their processing speed, independent of medications, cardiovascular risk factors, and comorbidities.
AB - Objective: To investigate the cross-sectional and longitudinal associations of 10-second heart rate variability (HRV) with various domains of cognitive function in older participants at risk of cardiovascular disease. Methods: We studied 3,583 participants, mean age of 75.0 years, who were enrolled in the Prospective Study of Pravastatin in the Elderly at Risk. From baseline 10-second ECGs, standard deviation of normal-to-normal intervals was calculated as the index of HRV. Four cognitive domains were assessed at baseline and repeated during a mean follow-up period of 3.2 years. Results: Lower HRV at baseline was associated with worse performance in reaction time (mean difference between low third vs high third of HRV 1.96 seconds, 95% confidence interval [CI] 0.20 to 3.71) and processing speed (-0.57 digits coded, 95% CI -1.09 to -0.05). During follow-up, participants with lower HRV had a steeper decline in processing speed (mean annual change between low third vs high third of HRV -0.16 digits coded, 95% CI -0.28 to -0.04). There was no difference in annual changes of reaction time or immediate and delayed memory among HRV thirds during follow-up. All these associations remained unchanged after adjustment for medications, cardiovascular risk factors, and comorbidities. Conclusions: Participants with lower 10-second HRV have worse performance in reaction time and processing speed and experience steeper decline in their processing speed, independent of medications, cardiovascular risk factors, and comorbidities.
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U2 - 10.1212/WNL.0000000000002499
DO - 10.1212/WNL.0000000000002499
M3 - Article
C2 - 26888988
AN - SCOPUS:84961659399
VL - 86
SP - 1120
EP - 1127
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 12
ER -