TY - JOUR
T1 - 18F-FDG and 68Ga-DOTATATE PET/CT in von Hippel-Lindau Disease-Associated Retinal Hemangioblastoma
AU - Papadakis, Georgios Z.
AU - Millo, Corina
AU - Jassel, Inderbir S.
AU - Bagci, Ulas
AU - Sadowski, Samira M.
AU - Karantanas, Apostolos H.
AU - Patronas, Nicholas J.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Retinal hemangioblastomas are highly vascular benign tumors that can be encountered either sporadically or within the von Hippel-Lindau (VHL) syndrome. We report a case of a VHL patient with retinal hemangioblastoma who underwent PET/CT scans using F-FDG and Ga-DOTATATE. The tumor showed low-level F-FDG and increased Ga-DOTATATE activity, suggesting cell-surface overexpression of somatostatin receptors. The presented case indicates the clinical applications of somatostatin receptor imaging with Ga-DOTA-conjugated peptides in detection and follow-up of VHL manifestations, screening of asymptomatic gene carriers, and in diagnosis of sporadic retinal hemangioblastomas, which may have similar features on MRI with other retinal tumors.
AB - Retinal hemangioblastomas are highly vascular benign tumors that can be encountered either sporadically or within the von Hippel-Lindau (VHL) syndrome. We report a case of a VHL patient with retinal hemangioblastoma who underwent PET/CT scans using F-FDG and Ga-DOTATATE. The tumor showed low-level F-FDG and increased Ga-DOTATATE activity, suggesting cell-surface overexpression of somatostatin receptors. The presented case indicates the clinical applications of somatostatin receptor imaging with Ga-DOTA-conjugated peptides in detection and follow-up of VHL manifestations, screening of asymptomatic gene carriers, and in diagnosis of sporadic retinal hemangioblastomas, which may have similar features on MRI with other retinal tumors.
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U2 - 10.1097/RLU.0000000000001511
DO - 10.1097/RLU.0000000000001511
M3 - Article
C2 - 28033220
AN - SCOPUS:85028254527
SN - 0363-9762
VL - 42
SP - 189
EP - 190
JO - Clinical nuclear medicine
JF - Clinical nuclear medicine
IS - 3
ER -