18F-FDG PET successfully detects spinal cord sarcoidosis

Kiyobumi Ota, Taiji Tsunemi*, Kazuyoshi TsunemiSaito, Fumika Yamanami, Mutsufusa Watanabe, Takashi Irioka, Hidehiro Mizusawa

*Corresponding author for this work

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Abstract Though there has been an array of methods to evaluate the extent of sarcoidosis, it is generally difficult to detect central nervous system involvement. Recently it has become accepted that 18F-FDG PET is more sensitive than gallium scintigraphy in finding sarcoid lesions, however its usefulness and limitations for detecting sarcoidosis in the central nervous system, especially in the spinal cord, has rarely been investigated. Two patients with pathologically confirmed sarcoidosis manifested spinal symptoms. We conducted 18F-FDG PET along with conventional imagings before and after treatment. Abnormal FDG uptakes which could not be detected by gallium scintigraphy were shown in the spinal cords in both patients. These abnormal uptakes were diminished in accordance with clinical improvement after treatment. Our findings suggest that 18F-FDG PET is effective in detecting and tracking the activity of spinal sarcoidosis.

Original languageEnglish (US)
Pages (from-to)1943-1946
Number of pages4
JournalJournal of Neurology
Volume256
Issue number11
DOIs
StatePublished - Nov 1 2009

Fingerprint

Fluorodeoxyglucose F18
Sarcoidosis
Spinal Cord
Gallium
Radionuclide Imaging
Central Nervous System
Therapeutics

Keywords

  • 18F-FDG PET
  • Cervical spondylosis
  • Gallium scintigraphy
  • Neurosarcoidosis
  • Sarcoidosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Ota, K., Tsunemi, T., TsunemiSaito, K., Yamanami, F., Watanabe, M., Irioka, T., & Mizusawa, H. (2009). 18F-FDG PET successfully detects spinal cord sarcoidosis. Journal of Neurology, 256(11), 1943-1946. https://doi.org/10.1007/s00415-009-5270-8
Ota, Kiyobumi ; Tsunemi, Taiji ; TsunemiSaito, Kazuyoshi ; Yamanami, Fumika ; Watanabe, Mutsufusa ; Irioka, Takashi ; Mizusawa, Hidehiro. / 18F-FDG PET successfully detects spinal cord sarcoidosis. In: Journal of Neurology. 2009 ; Vol. 256, No. 11. pp. 1943-1946.
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Ota, K, Tsunemi, T, TsunemiSaito, K, Yamanami, F, Watanabe, M, Irioka, T & Mizusawa, H 2009, '18F-FDG PET successfully detects spinal cord sarcoidosis', Journal of Neurology, vol. 256, no. 11, pp. 1943-1946. https://doi.org/10.1007/s00415-009-5270-8

18F-FDG PET successfully detects spinal cord sarcoidosis. / Ota, Kiyobumi; Tsunemi, Taiji; TsunemiSaito, Kazuyoshi; Yamanami, Fumika; Watanabe, Mutsufusa; Irioka, Takashi; Mizusawa, Hidehiro.

In: Journal of Neurology, Vol. 256, No. 11, 01.11.2009, p. 1943-1946.

Research output: Contribution to journalArticle

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Ota K, Tsunemi T, TsunemiSaito K, Yamanami F, Watanabe M, Irioka T et al. 18F-FDG PET successfully detects spinal cord sarcoidosis. Journal of Neurology. 2009 Nov 1;256(11):1943-1946. https://doi.org/10.1007/s00415-009-5270-8