Abstract
Abstract Though there has been an array of methods to evaluate the extent of sarcoidosis, it is generally difficult to detect central nervous system involvement. Recently it has become accepted that 18F-FDG PET is more sensitive than gallium scintigraphy in finding sarcoid lesions, however its usefulness and limitations for detecting sarcoidosis in the central nervous system, especially in the spinal cord, has rarely been investigated. Two patients with pathologically confirmed sarcoidosis manifested spinal symptoms. We conducted 18F-FDG PET along with conventional imagings before and after treatment. Abnormal FDG uptakes which could not be detected by gallium scintigraphy were shown in the spinal cords in both patients. These abnormal uptakes were diminished in accordance with clinical improvement after treatment. Our findings suggest that 18F-FDG PET is effective in detecting and tracking the activity of spinal sarcoidosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1943-1946 |
| Number of pages | 4 |
| Journal | Journal of Neurology |
| Volume | 256 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 1 2009 |
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Keywords
- 18F-FDG PET
- Cervical spondylosis
- Gallium scintigraphy
- Neurosarcoidosis
- Sarcoidosis
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
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18F-FDG PET successfully detects spinal cord sarcoidosis. / Ota, Kiyobumi; Tsunemi, Taiji; TsunemiSaito, Kazuyoshi; Yamanami, Fumika; Watanabe, Mutsufusa; Irioka, Takashi; Mizusawa, Hidehiro.
In: Journal of Neurology, Vol. 256, No. 11, 01.11.2009, p. 1943-1946.Research output: Contribution to journal › Article
TY - JOUR
T1 - 18F-FDG PET successfully detects spinal cord sarcoidosis
AU - Ota, Kiyobumi
AU - Tsunemi, Taiji
AU - TsunemiSaito, Kazuyoshi
AU - Yamanami, Fumika
AU - Watanabe, Mutsufusa
AU - Irioka, Takashi
AU - Mizusawa, Hidehiro
PY - 2009/11/1
Y1 - 2009/11/1
N2 - Abstract Though there has been an array of methods to evaluate the extent of sarcoidosis, it is generally difficult to detect central nervous system involvement. Recently it has become accepted that 18F-FDG PET is more sensitive than gallium scintigraphy in finding sarcoid lesions, however its usefulness and limitations for detecting sarcoidosis in the central nervous system, especially in the spinal cord, has rarely been investigated. Two patients with pathologically confirmed sarcoidosis manifested spinal symptoms. We conducted 18F-FDG PET along with conventional imagings before and after treatment. Abnormal FDG uptakes which could not be detected by gallium scintigraphy were shown in the spinal cords in both patients. These abnormal uptakes were diminished in accordance with clinical improvement after treatment. Our findings suggest that 18F-FDG PET is effective in detecting and tracking the activity of spinal sarcoidosis.
AB - Abstract Though there has been an array of methods to evaluate the extent of sarcoidosis, it is generally difficult to detect central nervous system involvement. Recently it has become accepted that 18F-FDG PET is more sensitive than gallium scintigraphy in finding sarcoid lesions, however its usefulness and limitations for detecting sarcoidosis in the central nervous system, especially in the spinal cord, has rarely been investigated. Two patients with pathologically confirmed sarcoidosis manifested spinal symptoms. We conducted 18F-FDG PET along with conventional imagings before and after treatment. Abnormal FDG uptakes which could not be detected by gallium scintigraphy were shown in the spinal cords in both patients. These abnormal uptakes were diminished in accordance with clinical improvement after treatment. Our findings suggest that 18F-FDG PET is effective in detecting and tracking the activity of spinal sarcoidosis.
KW - 18F-FDG PET
KW - Cervical spondylosis
KW - Gallium scintigraphy
KW - Neurosarcoidosis
KW - Sarcoidosis
UR - http://www.scopus.com/inward/record.url?scp=73449110242&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=73449110242&partnerID=8YFLogxK
U2 - 10.1007/s00415-009-5270-8
DO - 10.1007/s00415-009-5270-8
M3 - Article
C2 - 19685103
AN - SCOPUS:73449110242
VL - 256
SP - 1943
EP - 1946
JO - Journal of Neurology
JF - Journal of Neurology
SN - 0340-5354
IS - 11
ER -