1H-Pyrazole-1-carboxamidines: New inhibitors of nitric oxide synthase

Younghee Lee, Pavel Martásek, Linda J. Roman, Richard B. Silverman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


1H-Pyrazole-1-carboxamidines were prepared as potential inhibitors of the three isozymes of nitric oxide synthase. All of the compounds were found to be competitive inhibitors of all three isoforms. The most selective compound prepared was 1H-pyrazole-N-(3-aminomethylanilino)-1-carboxamidine (14), which is 100-fold selective for nNOS over eNOS with a K(i) value of 2μM. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)2771-2774
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number24
StatePublished - Dec 18 2000

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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