2 - Normal Brain Histopathology

Daniel J. Brat*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations


Surgical neuropathology can be challenging due to the intrinsic complexity of the human brain, yet a basic understanding of cell types and their organization is necessary. Much like pattern recognition is used for classifying diseases, so too can normal histology be approached based on tissue pattern recognition. Normal cells of the brain include neurons, glia, and microglia, as well as endothelial and perivascular cells, leptomeningeal cells, melanocytes, and choroid plexus. The morphologies, organization, and function of these cell types vary dramatically based on brain region, which is evident by the contrasting histologic features of the cerebral cortex and white matter, basal ganglia, thalamus, brainstem, cerebellum, and spinal cord, as well as specialized structures such as the pineal and pituitary glands and the hippocampus. The practice of surgical neuropathology also requires a familiarity with the features of the developing brain as well as those features associated with aging.

Original languageEnglish (US)
Title of host publicationPractical Surgical Neuropathology
Subtitle of host publicationA Diagnostic Approach A Volume in the Pattern Recognition Series
PublisherElsevier Inc
Number of pages19
ISBN (Print)9780323449410
StatePublished - Jan 1 2018


  • Brain
  • Cerebellum
  • Glia
  • Histology
  • Neurons
  • Spinal cord

ASJC Scopus subject areas

  • General Medicine


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