2-(Penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)thiophene, a novel NQO1 inducing agent from Echinops grijsii Hance

Jing Shi*, Xiaoyu Zhang, Hai Jiang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

A natural alkynol group-substituted thiophene, 2-(penta-1,3-diynyl)-5-(3,4- dihydroxybut-1-ynyl)-thiophene (PDDYT), was isolated from the roots of Echinops grijsii Hance. It possessed potent NAD(P)H: quinone oxidoreductase1 (NQO1) inducing activity and could activate Keap1-Nrf2 pathway effectively in murine hepatoma Hepa 1c1c7 cells. Further investigations indicated that the activation of Keap1-Nrf2 pathway by PDDYT might be attributed to the activation of Akt and depleting the cellular glutathione (GSH).

Original languageEnglish (US)
Pages (from-to)5273-5281
Number of pages9
JournalMolecules
Volume15
Issue number8
DOIs
StatePublished - Aug 2010
Externally publishedYes

Keywords

  • Akt
  • Echinops grijsii hance
  • Glutathione
  • NQO1
  • Nrf2
  • PDDYT

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of '2-(Penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)thiophene, a novel NQO1 inducing agent from Echinops grijsii Hance'. Together they form a unique fingerprint.

Cite this