Abstract
A natural alkynol group-substituted thiophene, 2-(penta-1,3-diynyl)-5-(3,4- dihydroxybut-1-ynyl)-thiophene (PDDYT), was isolated from the roots of Echinops grijsii Hance. It possessed potent NAD(P)H: quinone oxidoreductase1 (NQO1) inducing activity and could activate Keap1-Nrf2 pathway effectively in murine hepatoma Hepa 1c1c7 cells. Further investigations indicated that the activation of Keap1-Nrf2 pathway by PDDYT might be attributed to the activation of Akt and depleting the cellular glutathione (GSH).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5273-5281 |
| Number of pages | 9 |
| Journal | Molecules |
| Volume | 15 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2010 |
| Externally published | Yes |
Keywords
- Akt
- Echinops grijsii hance
- Glutathione
- NQO1
- Nrf2
- PDDYT
ASJC Scopus subject areas
- Drug Discovery
- Analytical Chemistry
- Chemistry (miscellaneous)
- Molecular Medicine
- Physical and Theoretical Chemistry
- Pharmaceutical Science
- Organic Chemistry