2-(Penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)thiophene, a novel NQO1 inducing agent from Echinops grijsii Hance

Jing Shi*, Xiaoyu Zhang, Hai Jiang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


A natural alkynol group-substituted thiophene, 2-(penta-1,3-diynyl)-5-(3,4- dihydroxybut-1-ynyl)-thiophene (PDDYT), was isolated from the roots of Echinops grijsii Hance. It possessed potent NAD(P)H: quinone oxidoreductase1 (NQO1) inducing activity and could activate Keap1-Nrf2 pathway effectively in murine hepatoma Hepa 1c1c7 cells. Further investigations indicated that the activation of Keap1-Nrf2 pathway by PDDYT might be attributed to the activation of Akt and depleting the cellular glutathione (GSH).

Original languageEnglish (US)
Pages (from-to)5273-5281
Number of pages9
Issue number8
StatePublished - Aug 2010
Externally publishedYes


  • Akt
  • Echinops grijsii hance
  • Glutathione
  • NQO1
  • Nrf2

ASJC Scopus subject areas

  • Drug Discovery
  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Physical and Theoretical Chemistry
  • Pharmaceutical Science
  • Organic Chemistry


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