20. Dissociating the functional properties of the medial and lateral anterior prefrontal cortex

E. Koechlin*, G. Corrado, P. Pietrini, J. Grafman

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The anterior prefrontal cortex (APC) is known to subserve higher cognitive functions like planning. However, little is known about the functional specialization within this region in humans. Using functional magnetic resonance imaging we report a double dissociation: the medial APC and the ventral striatum were engaged when subjects executed tasks in sequences that were fixed, whereas the polar APC and dorsolateral striatum were involved in task sequences that were contingent upon unpredictable events. These results parallel the functional segregation previously described in the premotor cortex suggesting common frontal organizational principles underlie motor and higher executive functions in humans.

Original languageEnglish (US)
Pages (from-to)93-97
Number of pages5
JournalBrain and Cognition
Volume47
Issue number1-2
StatePublished - Dec 1 2001

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology
  • Neuropsychology and Physiological Psychology

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