25-Hydroxyvitamin D3 (calcifediol) therapy of juvenile renal osteodystrophy: Beneficial effect on linear growth velocity

Craig B. Langman; Alice T. Mazur; Roland Baron; Michael E. Norman

doi:10.1016/S0022-3476(82)80602-1

25-Hydroxyvitamin D₃ (calcifediol) therapy of juvenile renal osteodystrophy: Beneficial effect on linear growth velocity

Craig B. Langman^*, Alice T. Mazur, Roland Baron, Michael E. Norman

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

A prospective study of renal osteodystrophy in moderate renal insufficiency was undertaken to assess the effects of 25(OH)D₃ (calcifediol) on healing of bone lesions and improvement of linear growth. One year after entering the study, the mean group growth velocity increased into the normal range and remained there in the next two therapy years. A significant correlation existed between pretherapy and one-year therapy values of growth velocity and serum 25(OH)D₃ concentration. Qualitative bone histology obtained by transilial bone biopsy was also evaluated during the course of study. Catch-up growth was not seen, but potential for such growth may exist in later years in our patients.

Original language	English (US)
Pages (from-to)	815-820
Number of pages	6
Journal	The Journal of pediatrics
Volume	100
Issue number	5
DOIs	https://doi.org/10.1016/S0022-3476(82)80602-1
State	Published - May 1982

Funding

From the Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, and the Department of Internal Medicine, Yale New Haven Hospital, Yale University School of Medicine. Supported in part by the Upjohn Company, Kalamazoo, Michigan. *Reprint address: Michael Reese Hospital and Medical Center, Department of Pediatrics, Division of Nephrology, Chicago, IL 60616.

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

Access to Document

10.1016/S0022-3476(82)80602-1

Cite this

@article{e784a8d86d8f4c02aac9b25e564d0aad,

title = "25-Hydroxyvitamin D3 (calcifediol) therapy of juvenile renal osteodystrophy: Beneficial effect on linear growth velocity",

abstract = "A prospective study of renal osteodystrophy in moderate renal insufficiency was undertaken to assess the effects of 25(OH)D3 (calcifediol) on healing of bone lesions and improvement of linear growth. One year after entering the study, the mean group growth velocity increased into the normal range and remained there in the next two therapy years. A significant correlation existed between pretherapy and one-year therapy values of growth velocity and serum 25(OH)D3 concentration. Qualitative bone histology obtained by transilial bone biopsy was also evaluated during the course of study. Catch-up growth was not seen, but potential for such growth may exist in later years in our patients.",

author = "Langman, {Craig B.} and Mazur, {Alice T.} and Roland Baron and Norman, {Michael E.}",

note = "Funding Information: From the Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, and the Department of Internal Medicine, Yale New Haven Hospital, Yale University School of Medicine. Supported in part by the Upjohn Company, Kalamazoo, Michigan. *Reprint address: Michael Reese Hospital and Medical Center, Department of Pediatrics, Division of Nephrology, Chicago, IL 60616.",

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AU - Mazur, Alice T.

AU - Baron, Roland

AU - Norman, Michael E.

N1 - Funding Information: From the Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, and the Department of Internal Medicine, Yale New Haven Hospital, Yale University School of Medicine. Supported in part by the Upjohn Company, Kalamazoo, Michigan. *Reprint address: Michael Reese Hospital and Medical Center, Department of Pediatrics, Division of Nephrology, Chicago, IL 60616.

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N2 - A prospective study of renal osteodystrophy in moderate renal insufficiency was undertaken to assess the effects of 25(OH)D3 (calcifediol) on healing of bone lesions and improvement of linear growth. One year after entering the study, the mean group growth velocity increased into the normal range and remained there in the next two therapy years. A significant correlation existed between pretherapy and one-year therapy values of growth velocity and serum 25(OH)D3 concentration. Qualitative bone histology obtained by transilial bone biopsy was also evaluated during the course of study. Catch-up growth was not seen, but potential for such growth may exist in later years in our patients.

AB - A prospective study of renal osteodystrophy in moderate renal insufficiency was undertaken to assess the effects of 25(OH)D3 (calcifediol) on healing of bone lesions and improvement of linear growth. One year after entering the study, the mean group growth velocity increased into the normal range and remained there in the next two therapy years. A significant correlation existed between pretherapy and one-year therapy values of growth velocity and serum 25(OH)D3 concentration. Qualitative bone histology obtained by transilial bone biopsy was also evaluated during the course of study. Catch-up growth was not seen, but potential for such growth may exist in later years in our patients.

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