Abstract
In this paper, a novel texture classification method from two-dimensional electrophoresis gel images is presented. Such a method makes use of textural features that are reduced to a more compact and efficient subset of characteristics by means of a Genetic Algorithm-based feature selection technique. Then, the selected features are used as inputs for a classifier, in this case a Support Vector Machine. The accuracy of the proposed method is around 94%, and has shown to yield statistically better performances than the classification based on the entire feature set. We found that the most decisive and representative features for the textural classification of proteins are those related to the second order co-occurrence matrix. This classification step can be very useful in order to discard over-segmented areas after a protein segmentation or identification process.
Original language | English (US) |
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Title of host publication | BIOINFORMATICS 2013 - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms |
Pages | 5-14 |
Number of pages | 10 |
State | Published - May 27 2013 |
Event | International Conference on Bioinformatics Models, Methods and Algorithms, BIOINFORMATICS 2013 - Barcelona, Spain Duration: Feb 11 2013 → Feb 14 2013 |
Other
Other | International Conference on Bioinformatics Models, Methods and Algorithms, BIOINFORMATICS 2013 |
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Country/Territory | Spain |
City | Barcelona |
Period | 2/11/13 → 2/14/13 |
Keywords
- Electrophoresis
- Feature selection
- Genetic algorithm
- Support vector machines
- Texture analysis
ASJC Scopus subject areas
- Biomedical Engineering
- Health Informatics
- Modeling and Simulation