3-Substituted alanines inactivate γ-aminobutyric acid aminotransferase by the same mechanism as DO 4-amino-5-halopentanoic acid analogues

Richard B. Silverman; Gregory T. Olson

doi:10.1016/0960-894X(95)00572-B

3-Substituted alanines inactivate γ-aminobutyric acid aminotransferase by the same mechanism as DO 4-amino-5-halopentanoic acid analogues

Richard B. Silverman^*, Gregory T. Olson

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

L-Serine O-sulfate inactivates γ-aminobutyric acid aminotransferase (GABA-AT) by a mechanism that involves elimination of the leaving group and an enamine rearrangement, the same mechanism as that for the inactivation of GABA-AT by 4-amino-5-fluoropentanoic acid.

Original language	English (US)
Pages (from-to)	143-146
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	6
Issue number	2
DOIs	https://doi.org/10.1016/0960-894X(95)00572-B
State	Published - Jan 23 1996

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/0960-894X(95)00572-B

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title = "3-Substituted alanines inactivate γ-aminobutyric acid aminotransferase by the same mechanism as DO 4-amino-5-halopentanoic acid analogues",

abstract = "L-Serine O-sulfate inactivates γ-aminobutyric acid aminotransferase (GABA-AT) by a mechanism that involves elimination of the leaving group and an enamine rearrangement, the same mechanism as that for the inactivation of GABA-AT by 4-amino-5-fluoropentanoic acid.",

author = "Silverman, {Richard B.} and Olson, {Gregory T.}",

note = "Funding Information: Acknowledgment. We are grateful to the National Institutes of Health financial support of this research.",

year = "1996",

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T1 - 3-Substituted alanines inactivate γ-aminobutyric acid aminotransferase by the same mechanism as DO 4-amino-5-halopentanoic acid analogues

AU - Silverman, Richard B.

AU - Olson, Gregory T.

N1 - Funding Information: Acknowledgment. We are grateful to the National Institutes of Health financial support of this research.

PY - 1996/1/23

Y1 - 1996/1/23

N2 - L-Serine O-sulfate inactivates γ-aminobutyric acid aminotransferase (GABA-AT) by a mechanism that involves elimination of the leaving group and an enamine rearrangement, the same mechanism as that for the inactivation of GABA-AT by 4-amino-5-fluoropentanoic acid.

AB - L-Serine O-sulfate inactivates γ-aminobutyric acid aminotransferase (GABA-AT) by a mechanism that involves elimination of the leaving group and an enamine rearrangement, the same mechanism as that for the inactivation of GABA-AT by 4-amino-5-fluoropentanoic acid.

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U2 - 10.1016/0960-894X(95)00572-B

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IS - 2

ER -

3-Substituted alanines inactivate γ-aminobutyric acid aminotransferase by the same mechanism as DO 4-amino-5-halopentanoic acid analogues

Abstract

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