3-Substituted alanines inactivate γ-aminobutyric acid aminotransferase by the same mechanism as DO 4-amino-5-halopentanoic acid analogues

Richard B. Silverman*, Gregory T. Olson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

L-Serine O-sulfate inactivates γ-aminobutyric acid aminotransferase (GABA-AT) by a mechanism that involves elimination of the leaving group and an enamine rearrangement, the same mechanism as that for the inactivation of GABA-AT by 4-amino-5-fluoropentanoic acid.

Original languageEnglish (US)
Pages (from-to)143-146
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number2
DOIs
StatePublished - Jan 23 1996

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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