3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium

Lizhi Xu, Sarah R. Gutbrod, Andrew P. Bonifas, Yewang Su, Matthew S. Sulkin, Nanshu Lu, Hyun Joong Chung, Kyung In Jang, Zhuangjian Liu, Ming Ying, Chi Lu, R. Chad Webb, Jong Seon Kim, Jacob I. Laughner, Huanyu Cheng, Yuhao Liu, Abid Ameen, Jae Woong Jeong, Gwang Tae Kim, Yonggang Huang & 2 others Igor R. Efimov*, John A. Rogers

*Corresponding author for this work

Research output: Contribution to journalArticle

233 Citations (Scopus)

Abstract

Means for high-density multiparametric physiological mapping and stimulation are critically important in both basic and clinical cardiology. Current conformal electronic systems are essentially 2D sheets, which cannot cover the full epicardial surface or maintain reliable contact for chronic use without sutures or adhesives. Here we create 3D elastic membranes shaped precisely to match the epicardium of the heart via the use of 3D printing, as a platform for deformable arrays of multifunctional sensors, electronic and optoelectronic components. Such integumentary devices completely envelop the heart, in a form-fitting manner, and possess inherent elasticity, providing a mechanically stable biotic/abiotic interface during normal cardiac cycles. Component examples range from actuators for electrical, thermal and optical stimulation, to sensors for pH, temperature and mechanical strain. The semiconductor materials include silicon, gallium arsenide and gallium nitride, co-integrated with metals, metal oxides and polymers, to provide these and other operational capabilities. Ex vivo physiological experiments demonstrate various functions and methodological possibilities for cardiac research and therapy.

Original languageEnglish (US)
Article number3329
JournalNature communications
Volume5
DOIs
StatePublished - Feb 25 2014

Fingerprint

epicardium
Pericardium
stimulation
Metals
cardiology
membranes
Membranes
Cardiology
Semiconductors
gallium nitrides
sensors
Sensors
Elasticity
Silicon
electronics
printing
Adhesives
Optoelectronic devices
Oxides
adhesives

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Xu, Lizhi ; Gutbrod, Sarah R. ; Bonifas, Andrew P. ; Su, Yewang ; Sulkin, Matthew S. ; Lu, Nanshu ; Chung, Hyun Joong ; Jang, Kyung In ; Liu, Zhuangjian ; Ying, Ming ; Lu, Chi ; Webb, R. Chad ; Kim, Jong Seon ; Laughner, Jacob I. ; Cheng, Huanyu ; Liu, Yuhao ; Ameen, Abid ; Jeong, Jae Woong ; Kim, Gwang Tae ; Huang, Yonggang ; Efimov, Igor R. ; Rogers, John A. / 3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium. In: Nature communications. 2014 ; Vol. 5.
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abstract = "Means for high-density multiparametric physiological mapping and stimulation are critically important in both basic and clinical cardiology. Current conformal electronic systems are essentially 2D sheets, which cannot cover the full epicardial surface or maintain reliable contact for chronic use without sutures or adhesives. Here we create 3D elastic membranes shaped precisely to match the epicardium of the heart via the use of 3D printing, as a platform for deformable arrays of multifunctional sensors, electronic and optoelectronic components. Such integumentary devices completely envelop the heart, in a form-fitting manner, and possess inherent elasticity, providing a mechanically stable biotic/abiotic interface during normal cardiac cycles. Component examples range from actuators for electrical, thermal and optical stimulation, to sensors for pH, temperature and mechanical strain. The semiconductor materials include silicon, gallium arsenide and gallium nitride, co-integrated with metals, metal oxides and polymers, to provide these and other operational capabilities. Ex vivo physiological experiments demonstrate various functions and methodological possibilities for cardiac research and therapy.",
author = "Lizhi Xu and Gutbrod, {Sarah R.} and Bonifas, {Andrew P.} and Yewang Su and Sulkin, {Matthew S.} and Nanshu Lu and Chung, {Hyun Joong} and Jang, {Kyung In} and Zhuangjian Liu and Ming Ying and Chi Lu and Webb, {R. Chad} and Kim, {Jong Seon} and Laughner, {Jacob I.} and Huanyu Cheng and Yuhao Liu and Abid Ameen and Jeong, {Jae Woong} and Kim, {Gwang Tae} and Yonggang Huang and Efimov, {Igor R.} and Rogers, {John A.}",
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Xu, L, Gutbrod, SR, Bonifas, AP, Su, Y, Sulkin, MS, Lu, N, Chung, HJ, Jang, KI, Liu, Z, Ying, M, Lu, C, Webb, RC, Kim, JS, Laughner, JI, Cheng, H, Liu, Y, Ameen, A, Jeong, JW, Kim, GT, Huang, Y, Efimov, IR & Rogers, JA 2014, '3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium', Nature communications, vol. 5, 3329. https://doi.org/10.1038/ncomms4329

3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium. / Xu, Lizhi; Gutbrod, Sarah R.; Bonifas, Andrew P.; Su, Yewang; Sulkin, Matthew S.; Lu, Nanshu; Chung, Hyun Joong; Jang, Kyung In; Liu, Zhuangjian; Ying, Ming; Lu, Chi; Webb, R. Chad; Kim, Jong Seon; Laughner, Jacob I.; Cheng, Huanyu; Liu, Yuhao; Ameen, Abid; Jeong, Jae Woong; Kim, Gwang Tae; Huang, Yonggang; Efimov, Igor R.; Rogers, John A.

In: Nature communications, Vol. 5, 3329, 25.02.2014.

Research output: Contribution to journalArticle

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T1 - 3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium

AU - Xu, Lizhi

AU - Gutbrod, Sarah R.

AU - Bonifas, Andrew P.

AU - Su, Yewang

AU - Sulkin, Matthew S.

AU - Lu, Nanshu

AU - Chung, Hyun Joong

AU - Jang, Kyung In

AU - Liu, Zhuangjian

AU - Ying, Ming

AU - Lu, Chi

AU - Webb, R. Chad

AU - Kim, Jong Seon

AU - Laughner, Jacob I.

AU - Cheng, Huanyu

AU - Liu, Yuhao

AU - Ameen, Abid

AU - Jeong, Jae Woong

AU - Kim, Gwang Tae

AU - Huang, Yonggang

AU - Efimov, Igor R.

AU - Rogers, John A.

PY - 2014/2/25

Y1 - 2014/2/25

N2 - Means for high-density multiparametric physiological mapping and stimulation are critically important in both basic and clinical cardiology. Current conformal electronic systems are essentially 2D sheets, which cannot cover the full epicardial surface or maintain reliable contact for chronic use without sutures or adhesives. Here we create 3D elastic membranes shaped precisely to match the epicardium of the heart via the use of 3D printing, as a platform for deformable arrays of multifunctional sensors, electronic and optoelectronic components. Such integumentary devices completely envelop the heart, in a form-fitting manner, and possess inherent elasticity, providing a mechanically stable biotic/abiotic interface during normal cardiac cycles. Component examples range from actuators for electrical, thermal and optical stimulation, to sensors for pH, temperature and mechanical strain. The semiconductor materials include silicon, gallium arsenide and gallium nitride, co-integrated with metals, metal oxides and polymers, to provide these and other operational capabilities. Ex vivo physiological experiments demonstrate various functions and methodological possibilities for cardiac research and therapy.

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